108 PARASITIC AMOEBAE OF MAN. 



interest to review briefly the experimental work re- 

 lating to the pathogenicity of Entamceba coli. Kar- 

 tulis experimented with amoebae obtained from 

 healthy individuals by injecting them into the intes- 

 tine of cats, but was not able to produce any patho- 

 logical lesions or symptoms of disease. The same 

 negative results were obtained by Kruse and Pas- 

 quale. One of the strongest arguments used by Celli 

 and Fiocca against the pathogenic action of amoebae 

 was the fact that they were not able to produce dysen- 

 tery in cats by the injection of amoebae from healthy 

 individuals, and the very careful experiments of 

 Kovacs were equally unsuccessful. Strong and Mus- 

 grave were also unable to produce dysentery in cats 

 with the amoebae found in health, and their comment 

 regarding their negative results is of interest. They 

 say " one of these cases which has been under our ob- 

 servation for several months has had these harmless 

 amoebae in his stools constantly during that time, yet 

 he has no dysentery and no history of any, and he 

 has no intestinal trouble. We have repeatedly in- 

 jected large numbers of these non-dysenteric amoebae 

 (amoeba coli) while motile in the stools, into the 

 rectum of cats, but with no eff ect. We have neither 

 been able to produce dysentery with them nor any 

 lesions of the large bowel on the other hand we 

 have had no difficulty in producing dysentery and 



