ON DUST AND DISEASE. 191 



series. Observed some days in the moist chamber, they 

 vegetated again, and appeared somewhat larger and 

 more conspicuous than immediately after their excre- 

 tion. It is to be noticed that only that kind of secretion 

 contains them which is expelled by violent sneezings ; 

 that which drops slowly does not contain any. They 

 stick tenaciously enough in the lower cavities and re- 

 cesses of the nose. 



' Whe,n I saw your first notice respecting the poison- 

 ous action of quinine upon infusoria, I determined at 

 once to make an experiment with that substance, 

 thinking that these vibrionic bodies, even if they did 

 not cause the whole illness, still could render it much 

 more unpleasant through their movements and the de- 

 compositions caused by them. For that reason I made 

 a neutral solution of sulphate of quinine, which did not 

 contain much of the salt (1'800), but still was effective 

 enough, and caused moderate irritation on the mucus* 

 membrane of the nose. I then lay flat on my back, 

 keeping my head very low, and poured with a pipette 

 about four cubic centimetres into both nostrils. Then 

 I turned my head about in order to let the liquid flow 

 in all directions. 



' The desired effect was obtained immediately, and 

 remained for some hours ; I could expose myself to the 

 sun without fits of sneezing and the other disagreeable 

 symptoms coming on. It was sufficient to repeat the 

 treatment three times a day, even under the most un- 

 favourable circumstances, in order to keep myself quite 

 free. 1 There were then no such vibrios in the secretion. 

 If I only go out in the evening, it suffices to inject the 



1 There is no foundation for the objection that syringing the 

 nose could not cure the asthma which accompanies hay fever ; for 

 this asthma is only the reflex effect arising from the irritation of 

 the nose. B. 



