790 THE ENDOCRINE ORGANS, OR DUCTLESS GLANDS 



ing in the same direction with regard to the glycogenic function are 

 developed: the one, a hypersecretion of epinephrine, which activates 

 the sympathetic nerve endings, the other, the transmission of the nerve 

 impulse to the liver cell (Macleod and R. G. Pearce). 34 



4. With the Pancreas. The function of the pancreas here concerned 

 is that of its supposed internal secretion from the Isles of Langerhans. 

 Since epinephrine readily produces glycosuria, and since excision of 

 the pancreas has the same effect, it has been natural to inquire whether 

 any relationship exists between the two glands, and some observers 

 have obtained results which they interpret as indicating that it does. 

 Certain observers even state that glycosuria does not occur after the 

 injection if at the same time extract of pancreas is injected. It is al- 

 most certain, however, that these results are not trustworthy. Thus, 

 removal of the adrenal glands in an animal suffering from pancreatic 

 diabetes does not restore any of the lost power of utilizing glucose 

 during the few hours that the animal remains alive. 34 That some rela- 

 tionship may, however, exist is indicated by the fact that epinephrine 

 causes dilatation of the pupil when it is dropped into the eye of a per- 

 son suffering from diabetes, whereas it has no such effect in the normal 

 individual. 



