TRANSFUSION. 99 



Since this time a great many experiments on transfusion 

 in animals have been performed, with very interesting results. 

 Provost and Dumas 1 have shown, that while an animal may 

 be restored after hemorrhage by the transfusion of defibrinated 

 blood, no such effect follows the introduction of the serum ; 

 showing that the vivifying influence in all probability resides 

 in the corpuscles. These observers have also shown, that 

 though an animal may be temporarily revived by the injection 

 of defibrinated blood from an animal of a different species, 

 death follows the operation in a few days. 2 Brown-Sequard 

 has shown that in parts detached from the body, after nervous 

 and muscular irritability have disappeared, these properties 

 may be restored for a time by the injection of fresh blood. 3 

 He also reports a curious experiment in which blood was 

 passed from a living dog into the carotid of a dog just dead 

 from peritonitis. The animal was so far revived as to sustain 

 himself on his feet, wag his tail, etc., and died a second time, 

 twelve and a half hours after. In this experiment insufflation 

 was employed in addition to the transfusion.* 



It may then be considered established, that in animals, 

 after hemorrhage, life may be restored by injecting the blood, 

 defibrinated or not, of an animal of the same species, pro- 

 vided it be introduced slowly, without admixture with air, 

 and not in too great quantity. If, however, the blood of an 

 animal of a different species be used, life will be restored but 

 for a short time. Death occurs after the transfusion of blood 

 in this instance, only when the animal receiving it is exsan- 

 guine, and the blood of an animal of a different species is 

 substituted. If the animal be not exsanguine, a little blood 

 can be superadded to the mass from an animal of different 

 species without this result, as is shown by the experiments 



1 BERARD, op. cit., tome iii., p. 219. 



2 MILNE-EDWARDS, Lemons sur la Physiologic et VAnatomie Comparee, tome i., 

 p. 322 et seq. 



3 Journal de la Physiologic, tome i., p. 106, 



4 Ibid., p. 668. 



