APPENDIX, 



ADDITIONS* AND NOTES TO VOLUME I. 



(1) Addition to p. 44, line 1 8. We must not forget that oxalate 

 of lime may possibly be formed during this process. We know 

 that there is a close connexion between the excretion of uric acid 

 and the formation of this salt, from the circumstance that in most 

 specimens of urine, both sedimentary and non-sedimentary, oxalate 

 of lime cannot be recognised by the microscope so long as the 

 fluid is fresh, but as soon as crystals of uric acid present them- 

 selves, crystals of oxalate of lime (at all events in small num- 

 bers) may also be discovered ; indeed, we generally find that in 

 morbid urine the abundance of these crystals is proportional to the 

 rapidity with which the free uric acid separates. Since uric acid, 

 when acted upon by certain oxidising agents, may be decomposed 

 into urea, allantoine, and oxalic acid, we may assume that a 

 portion of the uric acid may be decomposed during this acid urinary 

 fermentation, and that oxalic acid is formed from it, a possi- 

 bility which is converted into a probability by the recent observa- 

 tion of Ranke,f that uric acid, on the addition of yeast and of an 

 alkali, becomes decomposed at a high temperature into urea and 

 oxalic acid. 



(2) Addition to p. 48, line 3. Wb'hler and FrerichsJ have, how- 

 ever, shown by direct experiments that uric acid is decomposed in 

 the animal organism in precisely the same way as by peroxide of 

 lead, since they found that after the injection of urates there was 

 not merely an augmentation of the urea in the urine, but also that 

 oxalic acid was present in it in larger quantity. 



(3) Addition to p. 50, line 19. Scherer has likewise found 

 formic acid, in association with other acids of this group, in the 



* The "additions" are taken from the new German edition of this work 

 published-in 1853. 



f Journ. f. pr. Ch. Bd. 56, S. 16. 



t Ann. d. Ch. u. Tharm. Bd. (J5, S. 340. 



