ADDITIONS AND NOTES TO VOL. I. 46 1 



gramme of urea, while for 1 kilogramme's weight of the adult, 

 only 0'420 of a gramme (or little more than half the quantity) of 

 urea was excreted. 



[Subsequently to the publication of the first volume, Verdeil and 

 Dollfus* have found urea in large quantities in the blood of oxen. 

 Moleschottf believes that he has found oxalate of urea, together 

 with other oxalates, in the muscular juice of frogs, whose livers had 

 been some days previously extirpated. GroheJ has, however, 

 subsequently examined the constituents of the muscular juice of 

 frogs in the Giessen Laboratory, and has arrived at the following 

 results ; namely, 



1. That neither urea nor oxalic acid exists in this fluid ; and 



2. That the crystals supposed by Moleschott to consist of 

 oxalate of urea, in reality are composed of creatine, creatinine, 

 and nitrate of potash. G. E. D.] 



(15) Addition to p. Ifl, line 5. Chevallier and Lassaigne have 

 extracted a substance to which they have given the name xantho- 

 cystine, from the miliary tubercles in a dead body that had been 

 buried for two months. It was insoluble in water and alcohol, 

 but dissolved in ammonia and in the mineral acids ; the ammo- 

 niacal solution deposited minute white granules on evaporation ; 

 hexagonal tablets separated from the acid solutions on evapora- 

 tion ; the substance did not fuse on heating, but puffed up, became 

 yellow and black, and developed an odour of burned horn, and 

 gave off alkaline vapours. The investigation of this substance was 

 not carried any further. 



(16) Addition to p. l^l, line !? The following is the best 

 method of preparing hypoxarithine. The fluid obtained by boiling 

 the spleen with water is precipitated by baryta- water ; the filtered 

 fluid deposits baryta-salts on evaporation, and must be refiltered 

 and the baryta precipitated by sulphuric acid ; all these baryta- 

 precipitates contain hypoxanthine mixed with the phosphate, car- 

 bonate, and sulphate of baryta. It is extracted from them by a 

 dilute solution of potash, and is precipitated from this solution, 

 together with uric acid, by hydrochloric or carbonic acid. The 

 hypoxanthine may be obtained in a separate state by dissolving 



* Ann. d. Ch. u. Pharm. Bd. 74, S. 214. 

 t Arch. f. physiol. Heilk. Bd. 11, S. 493. 

 Ann. d. Ch.u. Pharra. Bd. 85, S. 

 Journ. de Chim. me'd. 3 S&-. T. 7, p. 208. 



