468 APPENDIX. 



taneously with Cl. Bernard*) that the portal blood contains no 

 sugar, or only traces of that substance, while the blood of the 

 hepatic veins is very rich in sugar. Bernard has satisfied himself 

 that the sugar in the vessels near the heart gradually diminishes, 

 and that only very little can be found in the arterial blood. 



(27) Addition to p. 289, line 3 from bottom. I have recently 

 found sugar in the urine of a man suffering from a very well-marked 

 attack of arthritis. 



Alvaro Reynosof has recently believed that he has found 

 sugar in the urine in various bodily conditions, especially in cases 

 of epilepsy and hysteria ; he further believes that sugar is con- 

 stantly to be found in the urine after narcotism has been induced 

 by the inhalation of ether, also in pulmonary affections, and after 

 the employment of the so-called hyposthenic agents, as metallic 

 salts, sulphate of quinine, narcotic drugs, &c. ; Uhle, who has had 

 opportunities of most carefully examining the urine in all these 

 conditions (for the most part under my own direct superinten- 

 dence), has never been able to confirm any one of Reynoso's 

 observations. 



Bernard^ found sugar in considerable quantity in the urine of 

 the foetus of the cow between the fifth and seventh months, and in 

 that of the sheep at two months. 



The same observer also found sugar in the fluids of the amnios 

 and allantois of the calf, lamb, and pig. In a seven months' foetal 

 calf, sugar was found in the urine ; but it no longer existed in the 

 above-mentioned fluids. 



(28) Addition to p. 290, 14 lines from the bottom. Bernard 

 has subsequently taken up this subject much more fully, while the 

 fact that sugar exists in the hepatic tissue has been thoroughly 

 confirmed by Frerichs,|| Baumert,^[ and myself. The amount of 

 sugar in the liver is much more considerable in many mammals 

 and birds than in reptiles, while in the liver of fishes there appears 

 to be no sugar. At all events, Bernard found no trace of sugar in 

 the liver either of the eel or of the skate. In many diseases the 

 sugar disappears from the liver. 



* Arch. g^n. de Md. T. 18, p. 303. 



t Compt. rend. T. 33. p. 410-416, p. 521, and T. 34, p. 18. 



| Ibid. Vol. 30, p. 317. 



Ibid. Vol. 31, p. 572-574. 



II Handworterbuch d. Physiologie. Bd. 3, Abt. 1, S. 831. 



f Journ. f. pr. Ch. Bd. 54, S. 357-363. 



