480 APPENDIX. 



(40) Addition to p. 349, line 21. During the last few years it 

 has been repeatedly maintained, that fibrin does not coagulate in 

 threads, but in lamellse. We may readily convince ourselves of the 

 accuracy of the description given in the text, if we will take the 

 trouble to use in the experiment inflammatoiy blood, in which the 

 red corpuscles sink rapidly and the fibrin coagulates slowly. 

 Funke has shewn in his Atlas (P. 19, F. 2) the coagulation of the 

 fibrin from a fresh drop of blood, according to E. H. Weber's 

 method ; but here, on the one hand, the red corpuscles disturb the 

 accuracy of the observation^ and, on the other hand, we might 

 regard the coagulation of the fibrin as the separation of a 

 laminated mass, which readily forms plaits or folds on which the 

 fibrillated appearance depends. The off-shooting of individual 

 threads from the molecular granules which first become apparent, 

 the projection of these threads, and their gradual augmentation in 

 various directions, can only be seen in blood with a buffy coat. 

 I am, however, unable to decide whether, at the final separation 

 of all the fibrin, these filaments subsequently increase in two 

 dimensions, that is to say, both increase in thickness and become 

 converted into lamellae or solid masses ; if we observe dried blood, 

 after the addition of water, with the microscope (as, for instance, 

 the thin section presented by a small spot of blood, such as is 

 often presented to us in medico-legal investigations), we see that 

 everything dissolves or disappears except the so-called lymph- 

 corpuscles and the fibrin ; under these circumstances, in conse- 

 quence, doubtless, of the thinness of the section, the fibrin certainly 

 appears in the form of pure lamellse, in which only a few distinct 

 duplicatures are visible. 



(41) Addition to p. 358, line 9. I* could not find a trace of 

 fibrin in the blood of the hepatic veins of the horse, while the 

 portal blood was always tolerably rich in that constituent. 

 Funke,t in his examination of the blood of the splenic vein, only 

 found a little fibrin in a few cases. 



(42) Addition to p. 359, line 20. Syntonin is the name I have 

 proposed for the substance which Liebig,J who was the first to 

 describe it accurately, has termed muscle-fibrin. The following are 

 its leading properties. When moist, it forms on the filter a 



* Ber. der Ges. d. Wiss. zu Leipzig. 1850, S. 136. 



t Dissert, inaug. de sanguine venae lienalis. Lips. 1850. 



Ann. d. Ch. u. Pharm. Bd. 73, S. 125-129. 



