532 APPENDIX. 



serous membranes (dropsy), by the action of the kidneys (albumi- 

 nuria), or by other losses of the juices whose action is manifested by 

 a diminution of albumen in the blood, certain quantities of the 

 albumen lost from the blood are replaced by certain quantities of 

 soluble salts, and here we must bear in mind that the salts are in 

 general accompanied by a definite quantity of water, which differs 

 from the amount associated with the albumen. The experiments 

 of Kierulf * have recently furnished a new proof of the correctness 

 of these observations, for he found that after a considerable quan- 

 tity of water had been injected into the veins, the amount of the 

 salts in the blood was rapidly and permanently increased. 



(33) Addition to p. 266, 11 lines from the bottom. In 

 leuccemia, which is commonly associated with a considerable 

 enlargement of the spleen, the entire mass of the blood exhibits 

 considerable similarity with the blood of the splenic vein (Virchow, 

 Scherer). The blood from the most different vessels is pale red, 

 often marked with whitish streaks arid very rich in colourless blood- 

 corpuscles ; within the body it coagulates into gelatinous flakes, 

 but when it coagulates in the air very little serum separates from 

 it; it exhibits an alkaline reaction, although the fluid which is 

 filtered from the coagulum has an acid reaction ; according to 

 Scherer's investigation, this blood contains true glutin, also a 

 body which ranks between glutin and albumen (an albuminous 

 substance containing phosphorus and iron), hypoxanthine, and 

 finally formic, acetic, and lactic acids. In other respects, accord- 

 ing to Scherer's analysis,f its quantitative composition is nearly 

 the same as that of normal blood in respect to the main consti- 

 tuents, excepting that the iron seems to be present in a somewhat 

 smaller quantity. 



(34) Addition to p. 266, 4 lines from the bottom. Becquerel 

 and Rodier have been led by their most recent analyses, which, how- 

 ever, are not very conclusive, to adopt the opinion that "the 

 essential anatomical character of scurvy must be sought in an 

 original modification of the fibrin," while they show that there is 

 an increase of the fibrin in the acute form of the idiopathic disease, 



' depending upon an excess of the soda-salts in the blood." 



(35) Addition to p. 270, line 11. The following method, based 



* Mitth. d. naturf. Ges. z. Zurich. Juli 1852. 



t Verh. d. physik-medic. Ges. zu Wurzburg. Bd. 2, S. 321-325. 



