ADDITIONS AND NOTES TO VOL. II. 539 



tion of Julius Vogel, deserve special notice ; the following were the 

 results which were obtained : an adult (whose bodily weight is 

 60 kilogrammes) discharges on an average 2*094 grammes of 

 sulphuric acid in 24 hours (Gruner). The amount of excreted 

 sulphuric acid rises during the period of digestion, falls somewhat 

 in the night, and is at its minimum in the forenoon (Gruner and 

 Jones). Active bodily exercise and mental excitement seem alone 

 able to influence the increased secretion of sulphuric acid in the 

 urine; moderate exercise does not influence it (Jones and Gruner). 

 Fasting does not diminish the excretion of sulphuric acid, at least 

 during the first 24 hours. This secretion is increased for a short 

 time, but afterwards proportionally diminished, by copious draughts 

 of water (Gruner). Sulphate of soda, potash or magnesia, is per- 

 fectly eliminated by the urine in 18 or 24 hours after it has been 

 taken (Gruner and Jones). The amount of sulphuric acid in the 

 urine also increases after the administration of sulphur. 



(45) . Addition to p. 402, line 19. Careful investigations have 

 been instituted by Breed* and by A. Winter, t in reference to the 

 amount of phosphoric acid in the urine. The mean of several 

 experiments on different individuals showed that there were 

 eliminated in the 24 hours from 3'765 to 5 '180 grammes (Winter), 

 or 3*732 'grammes (Breed). An increased use of fluids slightly 

 raises the number of the excreted phosphoric acid (Breed), but 

 according to Winter this is only observable in the first three or 

 four hours. In the night very much more phosphoric acid is 

 eliminated than in the morning, although then even less than at 

 noon (Winter). The amount of excreted phosphoric acid rises 

 very considerably after taking food (Breed and Winter). 



(46) Addition to p. 404, line 10. FalkJ has instituted very 

 careful investigations in reference to the same subject, and has 

 obtained very opposite results ; but three experiments are not 

 sufficient to warrant us in regarding this question as finally settled. 

 According to Falk's observations, water is eliminated in about six 

 hours after it has been taken, while a certain quantity of urine is 

 eliminated in a fasting state, even when no water has been intro- 

 duced into the organism. 



* Ann. d. Ch. u. Pharm. Bd. 78, S. 150-152. 



+ Beitrage zur Kenntniss der Urinabsonderung bei Gestmden. Inauguralabh. 

 d. med. Fac. zu Giessen vorgel. 1852. 



J Arch. f..physiol. Heilk. Bd. 12, 8. 150-155. 



