ADDITIONS AND NOTES TO VOL. IL 645 



food. C, Schmidt* had indeed made an experiment of this 

 nature on a cat;, and Bernard had been led from his observations to 

 maintain a similar view, but the experiments made under my 

 direction by Dr. von Becker were the first to convince me that 

 under at least apparently similar relations, sugar is quite as often 

 absent as present in the urine of rabbits after the use of highly 

 saccharine food (carrots), or after the injection of solutions of 

 sus^ar into the stomach of those animals. Certain relations which 



O 



exert a general influence on the secretion of urine, appear, more- 

 over, to exercise a special action on the urinary secretion. Thus 

 Dr. von Becker observed in several experiments that rabbits, into 

 whose stomachs a concentrated solution of sugar had been injected, 

 did not exhibit sugar in the urine unless the urinary secretion was 

 very abundant ; these animals continued perfectly well even when 

 as much as 60 grammes had been injected in the course of three 

 hours. Other rabbits, however, which exhibited morbid symptoms, 

 or which speedily died in consequence of excessive filling of the 

 stomach and intestines (as far as the transverse colon) with saturated 

 saccharine solutions, voided very little urine containing no sugar 

 whatever. It would appear, therefore, that sugar does not readily 

 pass into the urine when the quantity of the secretion is dimi- 

 nished. It is worthy of remark that only from 0*336 to 0'348<j of 

 sugar was found in the blood of those rabbits which retained their 

 healthy appearance and liveliness, whilst as much as from 1*03 to 

 1'20-g- of sugar was found accumulated in the blood of those 

 animals which apparently suffered after the injection of sugar, and 

 which secreted only small quantities of urine that was either very 

 poor in sugar, or entirely free from that substance. It would 

 appear, therefore, that when the quantity of sugar in the otherwise 

 normal blood exceeds 1--, the other limit is reached at which no 

 sugar passes into the urine, and at the same time the urinary 

 secretion is then reduced to the minimum. 



(54) Note to p. 428, line 13. [For much additional informa- 

 tion on the abnormal pigments of the urine, we may refer to the 

 Memoirs of Dr. A. II. Hassall,f read before the Royal Society, on 

 June 16, 1853, and June 15, 1854, " On the frequent occurrence 

 of indigo in human urine, and on its chemical, physiological, 

 and pathological relations ;" of Dr. Harley,J " On the colouring 



* Charakter. d. Cholera. S. 107. 



t Proceedings of the lloyal Society. Vol. C, p. 327, and Vol. 7, p. 122. 



Phann. Journ. Nov. 1852. 



VOL. III. 2 N 



