714 



METABOLISM 



functioning. Injected subcutaneously into completely depancreated dogs, 

 these extracts caused a marked lowering of blood sugar with great re- 

 duction in the sugar excretion by the urine and when the injections were 

 repeated daily the animals survived the operation for several weeks 

 longer than is usually the case and were in excellent condition. Later, 

 in collaboration with Collip, extracts were prepared by alcohol from 



fcl. 15 16 17 



Fig. 190-A. Curves showing effect of "insulin" in a case of diabetes mellitus. I, Daily 

 excretion of glucose in urine for periods before, during and after administration of Insulin; //, 

 Daily excretion of total ketone bodies before and during administration (from Jan. 23rd on); ///, 

 The effect of one injection (4 c.c. subcutaneously) of insulin on the blood sugar; IV, The two 

 hourly excretion of glucose for several days during administration. 



adult beef pancreas and their effects on human diabetes observed by 



Campbell and Fletcher. The results as shown in Fig. 190-A justify the 



ifiope that when this extract, for which the name "insulin" is suggested, 



\is given subcutaneously for some time to diabetic patients, the pancreas 



may reacquire its normal function, or at least, with control of the diet, 



