BLOOD PRESSURE 141 



each movement* Although the outflow from the narrow end of the tube 

 must remain constant, the pressure in the tubing will vary in proportion 

 to the viscosity of the gum solution (Bayliss 5 .) 



Transferring these results to an animal whose blood pressure has been 

 lowered by hemorrhage, it has been found that if saline solutions con- 

 taining a sufficient amount of gum acacia or gelatin to make the viscos- 

 ity about equal to that of blood, are injected, the original level of blood 

 pressure is recovered as well as it would be had blood itself been in- 

 jected. A 7 per cent solution of gum acacia almost fulfills these require- 

 ments, but unfortunately this solution contains a slightly greater amount 

 of calcium than it is safe to inject into an animal. The excess of calcium 

 may, however, be removed by exactly neutralizing the gum solution with 

 sodium hydroxide, neutral red being used as an indicator. Most of the 

 calcium becomes precipitated as phosphate. The mucilage of the British 

 Pharmacopeia, diluted five times with water, makes a 7 per cent solu- 

 tion of gum acacia. A 6 per cent solution of gelatin, after being heated 

 to 100 C., gives a viscosity similar to that of blood, but on account of 

 the possible presence of tetanus spores such solutions must be very care- 

 fully sterilized before injection, and the process of sterilization causes 

 a decrease in viscosity. The injection of a quantity of one of the above 

 solutions equal to that of blood lost by a hemorrhage will usually bring 

 the blood pressure back to its original height and hold it there for an 

 hour or so. 



Viscosity is, however, not. the only property of such solutions upon 

 which their desirable effect depends. The osmotic pressure of the colloids 

 also comes into play. By injecting saline solution containing a sufficient 

 amount of a colloid such as soluble starch, which gives it the correct 

 viscosity but has no osmotic pressure, the blood pressure, although it 

 temporarily recovers after transfusion, does not maintain its recovery in 

 the same way as with solutions containing gum or gelatin. The difference 

 between a starch solution and one of gum or gelatin is that the former 

 has no osmotic pressure, the effect of which is developed mainly on the 

 excretion of urine, as can be shown by observing the outflow from the 

 ureters during the injection into animals of equal quantities of saline 

 alone or of saline containing starch or gelatin (Knowlton 6 .) With the 

 first two fluids diuresis is produced, but not with gelatinous solutions. 

 The reason that the osmotic pressure of certain colloids prevents passage 

 of water from the blood into the urinif erous tubules is that the develop- 

 ment of -this pressure on the blood side of the renal epithejium tends to 

 counteract the filtration pressure by which the urine is formed (see 

 page 514.) 



Although the urinary factor will not in itself explain the efficiency of 



