40 



then absorbed. Repair of injured parts is effected b\ multi- 

 plication of tissue cells each tissue- after its kind. 



6. In reorganization, after a diminution in the intensity of 

 inflammation, the ne\v cells are organized either into cicatricial 

 or granular tissue. 



1 I ) Cicatricial tissue is seen in healing of closed wounds, 

 generally called healing by the first intention, and in chronic 

 inflammation of the kidney, liver, etc. Microscopically, the 

 cicatricial tissue is of spindle-shaped cells fibroblasts which, 

 according to some, are first epitheloid in nature, and then 

 become true connective tissue cells. Green writes also of a 

 sort of adenoid tissue of meshes of fibers inclosing lymphoid 

 cells. 



(2) Granular tissue is seen after suppuration in an ulcer or 

 open wound, and is termed union by the second intention. 

 The granulation tissue consists of roundish embryonic cells, 

 occurring in nodules or papillae upon developing loops of cap- 

 illaries below. The deeper layers develop into fibrillated 

 cicatricial tissue, while the surface cells appear as pus. Near 

 the normal epithelium, or grafts of epithelium made by the 

 surgeon, and under its influence, some of the pus cells, or 

 leucocytes, remain and become new epithelium. This new 

 epithelium is weaker than the normal, being thin and dry. 

 Fig. 7, PI. 2. 



,\ Infiltration. 



' Infiltration is a morbid affection usually depending upon 

 imperfect nutrition. The constitution of morbid fluids may 

 be considered as a kind of infiltration. Thus fluid pus may 

 be regarded as infiltrated with pus cells, serous fluid with 

 granular corpuscles, epithelium, etc., mucus with fungi, pus, 

 or blood, and milk with blood discs, granular corpuscles, etc. 

 In infiltrations, properly so called, the new material is not 

 derived from the tissue itself, but is deposited from the blood, 

 after producing a change of form or destruction of tissue. 

 Such depositions may occur from adulteration of the blood or 

 from local causes. Peculiarities of the tissues may influence 

 the form of infiltration. Thus the liver and areolar connective 



