CONTENTS. 



I. INFECTION- Page 



Course of infection 7 



II. IMMUNITY. 



Natural and acquired. Active and passive 12 



Theories of immunity: Klebs and Pasteur, Chauveau, Metchnikoff, Salmon 

 and Smith, !''<>. lor, Brhrin^ and Kimrr, Ehrlich's side chain theory; opsnnin 

 theory, Wright and Douglas; Neufeld and Rimpau 14 



III. OPSONIC INDEX. 



Irishman's method of estimating phagocytic power 23 



Wright and Douglas' opsonic index 23 



Serum; leucocytes; bacterial emulsion; strength of bacterial emulsion; mix- 

 ture of bacteria, leucocytes and serum; smears, preparation, fixing and 

 staining; examination of smears; calculation of the opsonic index 24 



IV. CRITICISMS AND MODIFICATIONS OF WRIGHT'S OPSONIC INDEX 

 DETERMINATIONS. 



Mechanical technique; serum; bacterial emulsions; leucocytes; calculation 

 and determination of the opsonic index, Simon, Strong; leucocytes ex- 

 amined 37 



V. OPSONIC INDEX IN HEALTH AND DISEASE. 



Importance of opsonins in immunity and accuracy of the method of deter- 

 mining the opsonic index; changes in opsonic index in disease; changes in 

 opsonic index due to vaccines 49 



VI. NATURE OF OPSONINS. 



Specificity; effect of heat; structure of opsonins; relation to leucocytosis; rela- 

 tion to stimulins; opsonins and aggressins; influence of chemicals and 

 reaction; non-bacterial opsonins 58 



VII. VACCINE THERAPY. 



Bacterial Vaccines: dosage; organisms used in vaccination; preparation of 



vaccines; control of injections, opsonic index and clinical 64 



Staphylococcus, streptococcus, gonococcus, pneumococcus, tuberculosis, colon 

 Bacillus, Bacillus typhosus, Bacillus dysenteriae, cholera, and less com- 

 mon infections 73 



Specific vaccines for diseases of unknown etiology: hydrophobia, small-pox. ... 81 

 Future of opsonins and vaccines 85 



VIII. SERUM THERAPY. 



Historical: Untoward effects of serum injections, serum disease and hyper- 

 susceptibility to serum; indications for immune serum injections; con- 

 centration and purification of serum; dried immune serum; oral adminis- 

 tration of serum 87 



Anti-toxic serum: Diphtheria antitoxin; tetanus anti-toxin 99 



Anti-bacterial serum: Anti-streptococcic syrum; anti-meningocoocic serum; 

 ;inti-gonococcic serum; anti-pneumococcic serum; anti-typhoid serum; 

 anti-dysenteric serum; anti-staphylococcic serum 109 



