PROTOCOLS OF EXPERIMENTS 



61 



Record of Guinea-pig 23, inoculated with rickettsia-infected 



louse W 224 



The temperatures following the inoculation on May 15th 

 were as follows : 



May 15 102.9 



May 22 102.4 



16 

 17 

 18 

 19 

 20 

 21 



103.0 

 102.6 

 102.7 

 103.0 

 102.7 

 103.1 



May 28th; killed. The autopsy was negative except for an 

 enlarged spleen covered with a tissue paper thin layer of trans- 

 parent fibrin-like material. Histologically the characteristic 

 lesions of typhus were found in the brain. 



Three guinea-pigs, Nos. 58, 59, and 60, were inoculated in- 

 traperitoneally, each with 2.5 c.c. of blood from this guinea- 

 pig, No. 23. 



The temperatures of these guinea-pigs were as follows: 



These animals were killed June 9th. The autopsies of all 

 were consistent with typhus in guinea-pigs. Guinea-pig 60 had 

 nodules of pseudo-tuberculosis in spleen, liver, and omentum, 

 but the lungs were normal. 



