108 SPECIFICITY OF RICKETTSIA PROWAZEKI 



On June 28th this guinea-pig was inoculated intraperitone- 

 ally with 5 c.c. of blood from patient 814 (eighth day of ty- 

 phus). The subsequent temperatures were as follows: 



F. F. 



June 28 102.5 July 12 103.1 



29 No record " 13 104.1 



30 . . 102.6 " 14 . . 103.6 



July 1 103.6 



2 No record 



3 104.4 



4 105.2 



5 ;... 104.8 



6 . . No record 



103.0 

 102.4 



9 No record 



10 102.7 



11 . . 102.6 



15 No record 



16 102.2 



17 102.1 



18 102.1 



19 102.6 



20 102.2 



21 No record 



22 102.1 



23 102.1 



24 102.6 



25 . . 102.4 



There is no record of an autopsy. 



Result: Following the inoculation with the viscera of 

 rickettsia-infected louse 4 of Box xxxvm, this guinea-pig 48 

 had two periods of elevated temperature, the second one cor- 

 responding in incubation period and duration with the tempera- 

 tures of typhus. After the injection of human typhus blood 

 there followed a rise of temperature on the fourth day, the 

 duration of which was influenced by the conditions of July 3d. 

 No other period of temperature occurred except that of July 

 13th and 14th, which corresponded to the usual incubation 

 of typhus in guinea-pigs inoculated with the blood of patient 

 814, but the course was not that of typhus; nevertheless the 

 immunity of guinea-pig 48 may be open to question. 



Conclusion: Rickettsia-infected louse 4 of Box xxxvm con- 

 tained the virus of typhus. 



