CLINICAL COURSE 145 



Subcutaneous inoculations were employed from time to time 

 as a means of eliminating mild secondary infections of the 

 peritoneum which frequently appeared. Repeated cultures 

 made from the heart's blood of guinea-pigs with a mild perito- 

 nitis in the early part of our work remained invariably sterile. 

 In one instance a micrococcus was obtained by direct culture 

 from the peritoneal cavity. 



2. CLINICAL COURSE OF TYPHUS IN GUINEA-PIGS 



The febrile reaction, discoverable only with the thermometer, 

 is the only sign of the typhus reaction in the vast majority of 

 instances. In our experience the guinea-pigs remain appar- 

 ently well, continue to eat, and behave as normal animals. 

 Pregnant females do not abort. The symptoms described by 

 Anderson (1914), listlessness and loss of weight, in our ex- 

 perience have been due to the severer reactions due to second- 

 ary infections. Death from typhus in guinea-pigs has occurred 

 very rarely. We have failed to make a careful study of th 

 occasional deaths in our passage animals, but we believe that 

 death occurring during the febrile period is always associated 

 with secondary infections. The rare deaths (three cases) 

 which we believe to have been due to uncomplicated typhus 

 have occurred after one or more days of normal temperature 

 during which the guinea-pigs have been paralyzed. The 

 paralysis is spastic and resembles that of rabies. This behavior 

 of typhus in guinea-pigs deserves more study. A typical ex- 

 ample is that of guinea-pig 219 which was inoculated Octo- 

 ber 11, 1920 (Box xvm). (See Chart 2.) 



Temperatures following inoculation: 



F. F. 



Oct. 11 102.4 Oct. 20 102.6 



12 102.5 21 103.8 



13 102.2 22 104.0 



14 102.5 23 104.5 



15 102.6 24 No record 



16 102.6 25 104.4 



17 No record 26 103.1 



18 101.7 27 103.2 



19 . . 102.6 28 . . 100.0 



