It will be noted that only Nos. 6, 8, and 10 failed to take the 

 scheduled amount oij preservative. No. 8 received the smallest 

 amount, taking only 0.1 gram on the first day of the last subperiod 

 and none thereafter, while Nos. 6 and 10 took only O'.l gram on the 

 next to the last day of the preservative period and none on the last 

 day, making a total for the subperiod of 0.7 gram. 



METHOD OF ADMINISTRATION. 



An aqueous solution of formaldehyde was administered in milk. 

 The strength of a stock solution was determined from time to time 

 and the proper volume to secure the amount required by the schedule 

 was added to the milk taken by the subjects. On account of the 

 liquid nature of this substance it was not possible to administer it in 

 any better way. The quantity added in the first subperiod was not 

 sufficient to impart any taste to the milk, but in the larger quantities 

 a slightly disagreeable taste was noticeable. In the case of half of 

 the men (Nos. 1 to 6) the preservative was added to the milk imme- 

 diately before it was drunk; and in order that ample time might be 

 given for any chemical union which might take place between the 

 formaldehyde and the protein constituents of the milk, that admin- 

 istered to Nos. 7 to 12 was added to the milk two days before con- 

 sumption. 



SUMMAEY OF RESULTS. 

 MEDICAL, AND CLINICAL DATA. 



The formaldehyde in the quantities administered did not produce 

 any marked symptoms until the third preservative subperiod, a lapse 

 of ten days; then headache and pain in the stomach and intestines 

 became general, in many cases producing cramps, and in a few cases 

 attended by nausea and vomiting. Only two exceptions are noted. 

 A burning sensation in the throat was reported in the majority of 

 cases. In four cases out of eleven a well marked itching rash appeared 

 on the chest and thighs, causing great discomfort, slight symptoms of 

 this nature being reported in a fifth case. The general symptoms, 

 therefore, are headache and abdominal pains, while a slight tendency 

 to lower the temperature may be noted as a minor symptom, and the 

 development of the rash, though marked, occurs in only about half 

 of the cases. 



It is important to observe that in the case of healthy young men it 

 requires some time for this drug to produce an effect noticeable in a 

 symptomatic way, as above described. That no effect is produced, 



[Cir. 42] 



