however, until after ten days would not be a logical conclusion. It is 

 evident that the system is able for some time to control the develop- 

 ment of conditions which later become pronounced, but that no ill 

 effects are produced prior to that time is not probable. After ten 

 days, however, ten cases out of twelve develop marked symptoms of 

 malaise, intestinal trouble, and distress, and in many cases positive 

 symptoms of a local character, such as the rash which has been men- 

 tioned. The apparent tendency to lower the temperature is men- 

 tioned as one of the symptoms, but inasmuch as no special investiga- 

 tion was made in this respect it is advisable that further studies be 

 prosecuted before positive statements are made, yet it is not without 

 signification that this unexpected condition of affairs was noticed, 

 and also that there was a tendency to its continuation in some 

 instances into the after period. (See figs. 1 and 2.) 



BODY WEIGHT. 



There is a slight tendency shown in the case of those subjects 

 receiving the formaldehyde directly in milk to a loss of body weight 

 under the administration of the preservative amounting to 0.2 kilo- 

 gram per day for each man, while in the case of the subjects receiving 

 milk preserved for forty-eight hours there does not appear to be any 

 noteworthy decrease in the body weight until the after period, when 

 an average loss of 0.5 kilogram is recorded. (See figs. 3 and 4.) 



The ratio of food weight to the body weight is practically constant 

 throughout the experiment. These changes in weight are of interest 

 as correlated with the corresponding increase in volume of the urine 

 and in the moisture in the feces, and as contrasted with the tendency 

 to decrease the excretion of the principal food elements studied. 



WEIGHT AND WATER CONTENT OF THE FECES. 



These data show, in the case of the subjects receiving formaldehyde 

 directly, an increase in moisture amounting to 2 per cent and a slight 

 decrease (1 gram per day) in the amount of dry feces excreted. In 

 the case of the subjects receiving the preservative forty-eight hours 

 after it had been added to the milk there is a decrease both in the 

 moisture content and in the weight of dry matter excreted, amount- 

 ing to 1.6 per cent and 3 grams daily, respectively, this decrease being 

 further augmented in the after period. There is thus shown a slight 

 derangement of the normal processes, which is unfavorable and 

 probably has some bearing on the loss of body weight. 



[Cir. 42] 



