16 



Table III. Comparative summary of principal determinations made Series VII. 



Data. 



Body weight (kilos) 



Composition of feces: 



Weight (grams) 



Water content (per cent) 



Dry matter (grams) 



Urine: 



Volume (cc) 



Microscopic sediments (per cent of 



relative occurrence) c 



Albumin (arbitrary values for relative 



occurrence) d 



Sulphur (asS0 3 ): 



Neutral 



Inorganic 



Ethereal 



Total 



Metabolism (percentage results): 

 Nitrogen 



Nonmetabolized (feces) 



Metabolized (urine) 



Phosphoric acids: 



Nonmetabolized (feces) 



Metabolized (urine) 



Sulphur: 



Nonmetabolized (feces) 



Food sulphur only 



Including S in preservative 



Metabolized (urine) 



Food sulphur only 



Including S in preservative 



Sodium sulphite (Nos. 1-6). 



Fore 

 period. 



63.71 



82.00 

 72.50 

 23.00 



,092.00 



54.50 







.312 

 2.164 



.165 

 2.642 



7.50 

 85.10 



29.93 

 60.03 



11.20 



82.55 



Preserv- 

 ative 

 period. 



62.78 



103.00 

 76.15 

 25.00 



1,139.00 



66.70 



13 



.419 

 2.729 



.167 

 3.316 



8.54 

 87.17 



36.34 

 58.82 



12. 13 

 10.16 



106.66 



After 

 period. 



62.28 



85.00 

 75.40 

 21.00 



1, 076. 00 



65.50 



7 



.372 

 2.104 



.156 

 2.631 



7.47 



88.17 



29.91 

 57.60 



10.05 



85.32 



Sulphurous acid (Nos. 8-11). b 



Fore 

 period. 



87.00 

 74.97 

 22.00 



1, 195. 00 



.281 



1.943 



.140 



8.04 

 80.55 



32.81 

 53.66 



11.05 

 74.09 



Preserv- 

 ative 

 period. 



62.00 



102. 00 

 76.60 

 24.00 



1,402.00 



.371 

 2. 249 



.155 

 2.774 



8.78 

 79.10 



37.13 



52.85 



11.85 

 10.42 



After 

 period. 



62.07 



115.00 

 77.63 

 26.00 



1,415.00 



.409 

 2.016 



.142 

 2.567 



9.26 

 81.13 



36.66 

 51.01 



80.31 



Received an average of 0.472 gram per day of SO-. 

 & Received an average of 0.343 gram per day of SOo." 

 c Nos. 1 to 12. 



d Calculated only for subjects who showed no albumin in fore period, including Nos. 1 

 to 12. 



GENERAL CONCLUSIONS. 



From a careful consideration of the data in the individual cases, 

 and the summaries of the results, it appears that the administration 

 of sulphurous acid in the food, either in the form of sulphurous-acid 

 gas in solution or in the form of sulphites, is objectionable and pro- 

 duces serious disturbances of the metabolic functions and injury to 

 digestion and health. This injury manifests itself in a number of dif- 

 ferent ways, both in the production of clinical symptoms which indi- 

 cate serious disturbances, malaise, or positive suffering, and also by 

 inducing certain changes in the metabolic processes which are not 

 manifested in the way of ordinary clinical symptoms, and are only 

 detected by careful chemical and microscopical study of the excretory 

 products. It can be safely said from the evidence adduced that the 

 administration of sodium sulphite and sulphurous acid, as above indi- 

 cated, produces a marked influence of an unfavorable character on 

 metabolism. As a result of this action, an assimilation of food mate- 

 rials containing organic phosphorus is retarded, while there is evi- 

 dence of increased sulphur katabolism. The sulphur balance sheets 



[Cir. 37] 



