12 



would indicate any lesions produced, as would be evidenced by a 

 large increased production of the various casts, but the data taken as 

 a whole indicate a strong tendency on the part of the preservative to 

 produce an increased renal activity as evidenced by the general 

 increase of the microscopic bodies. 



Distribution of Nitrogenous Bodies. 



In the special study (Series XI) made to determine the effects of 

 the preservative on the distribution of the nitrogen-bearing bodies 

 in the urine, there is shown a decrease in the quantity of urea excreted 

 during the preservative period. There is also a decrease in the total 

 nitrogen excreted which is contrary to the tendency shown in Series 

 VII. For the reasons given under the discussion of the volume of 

 the urine the data for Series VII must be given greater weight. 



The other bodies remain very constant. There is a tendency to 

 slightly decrease the amounts of uric acid and ammonia, under the 

 influence of the preservative, while kreatinin is slightly increased. 

 This disturbance, the decrease of urea and the increase of kreatinin, 

 shows an interesting relation in so far as the normal processes in 

 regard to the excretion of these bodies is concerned. Urea, which of 

 all the materials excreted contains the largest amount of nitrogen, is 

 believed by some to be an indication of the proteid metabolism. 

 Recently the excretion of kreatinin has received more attention and 

 is regarded by Folin and others as an index to katabolic changes, as 

 during normal metabolism it should remain constant. 



The fact that here one is decreased, while the other is increased, is 

 quite significant, and, considered in connection with other disturb- 

 ances noted, shows that the preservative has exerted a marked in- 

 fluence in deranging the metabolic functions. 



Sulphur. 



Under the conditions of the experiment the sulphur studies present 

 especially interesting data. 



As would be expected, the quantity of inorganic sulphates excreted 

 in the urine is very largely increased by the administration of sul- 

 phurous acid and sulphite, this increase, whether sulphite or sul- 

 phurous acid was ingested, accounting for the greater part of the 

 preservative sulphur eliminated. 



In addition to the increase in inorganic sulphates, an important 

 fact brought out by the data is the increase in the organic combina- 

 tion of sulphur, known as neutral sulphur. This sulphur was uni- 

 formly increased in every case during the preservative period, and in 

 some instances, particularly in the subjects receiving sulphurous acid, 



[Cir. 37] 



