11 



note this tendency in connection with that of other salts classified as 

 purgatives, and the other disturbances caused by the preservative. 



There was a larger quantity of dry matter excreted in the feces 

 under the administration of the preservative, showing a tendency to 

 decrease to this extent the absorption of the food from the intestinal 

 canal. There is thus manifested a tendency on the part of this pre- 

 servative to derange the metabolic process in so far as these changes 

 in the composition of the feces are concerned. 



THE URINE. 

 Volume and Acidity. 



A notable effect of the preservative upon the urine in Series VII 

 was in the increase in volume, thus showing a slight tendency to pro- 

 duce a diuretic effect. This tendency to diuresis is more marked in 

 the cases where sulphurous acid is given in a free state than when it is 

 combined as sulphite. The total solids in the urine were also slightly 

 increased, and there was a marked tendency to increase the acidity, 

 especially in the case of the administration of sodium sulphite. It is 

 evident, therefore, that sulphurous acid has a disturbing effect upon 

 the excretion of the urine, and this effect in general is confirmed by 

 the special Series XIII, in Avhich the sodium sulphite produced a very 

 slight reduction in volume, while sulphurous acid again showed a 

 diuretic effect. 



In the special Series XI no diuretic effect is shown. It must be 

 noted, however, that only three subjects took part in this experiment, 

 none of whom was in the original series, and the time of year also may 

 have influenced this result to the slight extent shown, inasmuch as 

 Series XI was conducted in the spring and Series VII in the winter. 



Presence of Albumin. 



The data which have been recorded for Series VII and XI show 

 unmistakable evidence that the preservative in certain cases produced 

 albuminuria. In the cases in which traces of albumin are present 

 in the fore period, however, there is no proof that the condition was 

 accentuated by the preservative. A further study will be necessary 

 to definitely establish this point. 



Microscopic Bodies. 



In general, there is shown an increase in the various bodies indi- 

 cated in the routine examination, particularly in the case of mucous 

 strands and mucous cylindroids. There was no evidence shown which 



[Cir. 37] 



