LETTER OF TRANSMITTAL 



U. S. DEPARTMENT OF AGRICULTURE, 



BUREAU OF CHEMISTRY, 

 Washington, D. C., November 18, 1912. 



SIR: I have the honor to submit for your approval a manuscript 

 on the elimination and toxicity of caffein in nephrectomized rabbits, 

 which is the third of a series of reports on caffein being made by the 

 Pharmacological Laboratory of the Division of Drugs in connection 

 with the enforcement of the food and drugs act. The first two 

 numbers of the series are Bulletins 148 and 157. I recommend that 

 this manuscript be published as Bulletin No. 166 of the Bureau of 

 Chemistry. 



Respectfully, R. E. DOOLITTLE, 



Acting Chief. 

 Hon. JAMES WILSON, 



Secretary of Agriculture. 



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