CONTENTS. 



Page. 



Elimination of caffein in nephrectomized rabbits 7 



Introduction 7 



Review of the literature 7 



Experiments 10 



Elimination of caffein during the first 22 hours (Series I, II, and III). 11 



Elimination of caffein in from 7 to 28 hours (Series IV) 12 



Elimination of caffein in from 1 to 3 hours (Series V) 13 



Elimination of caffein in 4 hours (Series VI) 14 



Elimination of caffein in 6 hours (Series VII) 15 



Elimination of caffein in 21 hours, 5 and 7 days (Series VIII) 15 



Elimination of caffein in rabbits in which urine was scanty or absent 



(Series IX) 16 



Elimination of caffein in rabbits in which urine was abundant (Series 



X) 17 



Results of experiments 18 



Toxicity of caffein in nephrectomized rabbits 20 



Introduction 20 



Experiments 22 



Cumulation with moderately large doses (Series I) 22 



Cumulation with smaller doses (Series II) 22 



Cumulation with small doses (Series III) 23 



Test for the presence of substances antagonistic to caffein (Series IV 



and V). . . . -. 25 



Further tests, with medium doses, for the toxicity of caffein (Series VI) . 28 



Effect of operation on toxicity (Series VII) 29 



Resum and discussion 30 



Conclusions 31 



Bibliography 31 



5 



