18 



CAFFEIN IN NEPHRECTOMIZED KABBITS. 



September 7, 1912: 12.00 m., received 14.5 cc of 2 per cent caffein injected subcu- 

 taneously, or 150 mg per kilo; 4.05 p. m., bladder emptied; rabbit chloroformed; total 

 urine, 110 cc. Per cent caffein recovered in urine, 4.34; stomach, 4.83; intestines, 

 6.98; total, 16.15. 



Rabbit 858. September 7, 1912: 11.45 a. m., received 16 cc of 2 per cent caffein, 

 or 150 mg per kilo; bladder empty; 4 p. m., bladder emptied and the rabbit chloro- 

 formed; total urine, 60 cc. Per cent caffein recovered in urine, 3.69; uterus, 3.00; 

 stomach, 2.72; intestines, 6.9; total, 16.25. 



Rabbit 859. Diet, oats and cabbage; water consumed, 100 cc for three days. 



September 7, 1912: 11.20, bladder emptied, received 12.25 cc of 2 per cent caffein, 

 injected subcutaneously, drank 65 cc of water; 3.40, bladder emptied, animal 

 chloroformed; urine, 100 cc. Per cent caffein recovered in urine, 3.72; stomach, 

 4.08; intestines, 8.53; total, 16.33. 



In the above experiments the amount of caffein recovered from 

 the contents of the stomach and intestines was from 8.35 to 12.61 

 per cent, while in Series IX the amount varied between 12.1 and 14.9 

 per cent, thus pointing to a decided increase in the eliminative func- 

 tion of the gastrointestinal canal when the kidney is unable to elimi- 

 nate this substance. This is also shown when the kidneys were 

 entirely removed, in Series VI, as well as in the experiments with 

 rabbits Nos. 742 and 743 (p. 13). 



RESULTS OF EXPERIMENTS. 



Elimination of caffein in normal rabbits. 



1 15 cc urine; no caffein. 2 No urine. 

 Elimination of caffein in nephrectomized rabbits. 



