BIBLIOGRAPHY. 31 



CONCLUSIONS. 



The data presented in the present investigation justify the follow- 

 ing conclusions: 



1. The removal of both kidneys in the rabbit stimulates to a 

 marked degree the elimination of caffein by the stomach, and to a 

 greater degree the elimination by the intestine. 



2. The amounts of caffein found several hours after injection com- 

 pared with the amounts recovered about 24 hours after injection 

 indicate that absorption goes on f,;multaneously with excretion. 

 That reabsorption takes place is shown by the absence of caffein from 

 the gastrointestinal canal and by the presence of very small quanti- 

 ties of it in the feces of nephrectomized rabbits which lived 5 to 7 

 days after the injection. 



3. Elimination is most active during the first few hours after injec- 

 tion of caffein, being more rapid by the intestine than by the kidney. 



4. The undiminished resistance to the single dose and tolerance 

 for large amounts of caffein when subminimum doses are injected at 

 sufficiently long intervals points to the formation of substances 

 antagonistic to caffein after the removal of both kidneys. 



BIBLIOGRAPHY. 



1. Archard and Loper. Compt. rend. Soc. biol., 1902, 54: 338. 



2. - . Compt. rend. Soc. biol., 1902, 54: 1480. 



3. - . Compt. rend. Soc. biol., 1902, 54: 1841. 



4. Bernard, Claude. Rev. cours scientifique, 1865, 2: 179. 



5. - . Lecons BUT les autointoxications dans les maladies, 1872, p. 19. 



6. Bing. Berl. Klin. Woch., 1905, 42: 1278. 



7. Bouchard. Sur les intoxications, 1889, pp. 21 and 213. 



8. Grigaut and Richet. Compt. rend. Soc. biol., 1912, 72: 143. 



9. Hanford. Amer. J. Phys., 1903, 9: 214. 



10. Jackson and Saiki. Archives of Internal Medicine, 1912, 9: 79. 



11. Javal. Sem. Med., 1903, 23: 224. 



12. Kleiner. J. Exper. Med., 1911, 14: 274. 



13. Loeb and Fleischer. J. Exper. Med., 1910, 12: 487. 



14. Loofs. Deut. Arch. Klin. Med., 1911, 103: 563. 



15. McCallum. Univ. Calif. Publications, Physiology, 1904, /; 125. 



16. Meltzer and Langmann. J. Med. Research, 1903, 9: 19. 



17. Meltzer and Lucas. J. Exper. Med., 1907, 9: 298. 



18. Meltzer and Salant. J. Med. Research, 1903, 11: 30. 



19. Mendel and Benedict. Amer. J. Phys., 1909, 25: 1. 



20. Mendel and Closson. Amer. J. Phys., 1906, 16: 152. 



21. Mendel and Sicher. Amer. J. Phys., 1906, 16: 147. 



22. Mendel and Thacher. Amer. J. Phys., 1904, 11: 5. 



23. Meyer. J. Biol. Chem., 1907, 2: 461. 



24. Powers. Dublin J. Med. Sci., 1882, p. 369. 



25. Roger and Gamier. Compt. rend. Soc. biol., 1912, 72: 739. 



26. Salant and Meyer. Amer. J. Phys., 1907, 20: 366. 



27. Salant and Rieger. U. S. Dept. Agr., Bureau of Chemistry Bui. 157. 



28. Von Noorden. Metabolism and Practical Medicine. 1907, vol. 2. 



29. Widal and Javal. J. med. francois., 1911, 5. 18. 



30. Zezschwitz. Diss. Erlangen, 1883. 



