EXCRETION OF BEN ZOIC AND HIPPURIC ACIDS. 



Hippuric acid is the most important natural constituent of the 

 urine of herbivorous animals whose food contains large quantities 

 of aromatic substances which, either by oxidation or reduction, are 

 converted into bodies containing the benzene nucleus. The benzene 

 nucleus by combination with glycocoll is converted into hippuric 

 acid, in which form it is excreted. Hippuric acid is a normal con- 



MAY 



56 



68 



67 



68 



62 



63 



RECEIVED BENZ01C ACID:E 



SUMMARY Ns 7-8-9-10-1 1-12 



^RECEIVED , SODIUM BENZOATE 



SUMMARY N. s h2-4-S-6-7-8-9-KHH2 



FORE PERIOD PRESERVATIVE PERIOD AFTER PERIOD 



FIG. 2. Average body weights for Series VIII, Nos. 10-12, and summaries. 



stituent of the urine and the data show a fact, already well recog- 

 nized by physiologists, namely, that the administration of benzoic 

 acid or benzoate of soda to the human animal increases the quantity 

 of hippuric acid so excreted. The limit of conversion of benzoic 

 acid into hippuric acid is determined by the quantity of available 

 glycocoll. Any excess of benzoic acid over the quantity which can 

 thus be converted into hippuric acid is excreted as benzoic acid. 



[Cir. 39] 



