The greater care which is required in the manufacture of food prod- 

 ucts without the use of benzoic acid or benzoate of soda, necessitating 

 the use of a higher quality of raw material, will place the industries 

 which would otherwise use these preservatives in foods on a better 

 plane, and secure for their products a greater consumption. 



ADMINISTRATION OF THE PRESERVATIVE. 



In Table I are recorded the dates of the periods and subperiods 

 during which this experiment was conducted. A preliminary or 

 relaxation period of one month elapsed between the close of Series 

 VII and the beginning of Series VIII, the subjects being the same 

 in both series, with the exception of No. 4. 



TABLE I. Dates of periods and subperiods in Series'VIII. 



In Table II is given a schedule of the administration of the pre- 

 servative. The sodium benzoate used is calculated in the table as 

 benzoic acid. The preservative was given in all cases in capsules, as 

 experience had shown this to be the best method from every point 

 of view of administering a substance of this nature. 



In the first preservative subperiod there was given to Nos. 1 to 6, 

 inclusive, 1 gram of benzoic -acid per day; to Nos. 7 to 12, inclu- 

 sive, 1 gram per day, with the exception of the first day, when only 

 0.9 gram was given. During the second preservative subperiod 1.5 

 grams of benzoic acid were given each day to each member. In the 

 third preservative subperiod 2 grams and in the fourth 2.5 grams 

 were given each day, with the exceptions noted in the table. There 

 were several cases during the fourth subperiod when the preservative, 

 by reason of its ill effects and for other causes, had to be withdrawn. 

 The maximum quantities of benzoic acid, therefore, given during the 

 entire preservative period are 35 and 34.9 grams, and only three men 

 were able to take these amounts. In all of the other cases it Avas 

 necessary to withdraw a portion or all of the preservative, for the 

 reasons already stated. 



[Cir. 39] 



