United States Department of Agriculture, 



BUREAU OF CHEMISTRY Circular No. 31. 



H. W. WILEY, Chief of Bureau. 



GENERAL RESULTS OF THE INVESTIGATIONS SHOWING THE EFFECT 

 OF SALICYLIC ACID AND SALICYLATES UPON DIGESTION AND 

 HEALTH. 



ORGANIZATION OP THE EXPERIMENT. 

 CONTKOL OF SUBJECTS. 



The experiments were conducted on twelve young men volunteers, 

 chiefly from the Department of Agriculture, who voluntarily assumed 

 the obligations imposed by work of this kind. They pledged them- 

 selves to abide by the rules and regulations guiding their conduct 

 during the period of the observation, to indulge in no unusual exer- 

 cise or study, to pursue the ordinary tenor of their daily lives without 

 any more variation than is incident to regular habits. They further 

 undertook to eat only the food which was given them at the hygienic 

 table, to collect and deliver for analysis the excreta of their bodies, 

 to observe regular hours respecting sleep and work, and to report 

 the quantity of water which was drunk away from the hygienic table. 

 The young men were not placed under surveillance, but simply were 

 trusted with their pledge that they would not violate any of the rules 

 of conduct prescribed. 



THE RATION. 



The work was conducted in a manner which has already been de- 

 scribed, b namely, by first ascertaining in the fore period the quantity 

 of food necessary to satisfy the ordinary demands of hunger and 



a By reason of the restrictions placed upon the printing and distribution of the bulletins 

 of the Department of Agriculture, it is not possible to supply the demand for Bulletin 84, 

 Influence of Food Preservatives and Artificial Colors on Digestion and Health, from the 

 regular edition. In order to meet this demand and to give as wide a circulation as possible 

 to the results of the experimental work, it has been deemed advisable, in the case of Part 

 II on Salicylic Acid and Salicylates, as with Part I, Boric Acid and Borax, to publish the 

 general results in the form of a circular for more general distribution. In explanation of 

 results obtained in this circular, attention is called to the fact that the methods pursued 

 in the investigation were essentially those described in Bulletin 84, Part I, and in Circular 

 15, Results of Borax Experiment. 



& Circular 15, Bureau of Chemistry, U. S. Dept. of Agriculture. 



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