studies, that the energy developed by each individual remains prac- 

 tically constant, any increased absorption of food materials should 

 have been followed by an increase in body weight. On the con- 

 trary, as is shown in the study of the balances, the katabolic activities 

 are increased more strongly than the anabolic. There is a more 

 vigorous tearing down of the tissues of the tody than there is a 

 building up thereof, and thus the observations made in the clinical 

 and medical history are thoroly corroborated by the chemical studies 

 of the foods and the products of metabolism. The general study of 

 the medical data shows in some instances decidedly unfavorable 

 symptoms attending the use of salicylic acid, while in a minority of 

 cases no unfavorable symptoms of a diagnostic character are devel- 

 oped. After carefully weighing all the data favorable and unfavor- 

 able to the salicylic acid, disclosed in the detailed statement of the 

 medical history, the conclusion is inevitable that taken as a whole 

 the effects produced by its administration are unfavorable. It is 

 true that there are individual cases which, taken alone, would lead 

 presumably to a contrary opinion, and to these due weight is given 

 in the general conclusion. As a jury considering conflicting testi- 

 mony gives weight to that which seems most convincing and least 

 open to doubt, so in the decision of this case from the medical history 

 the verdict must follow the weight of testimony and be given against 

 the defendant, namely, salicylic acid. 



A summary of the most important indications leading to these 

 conclusions is as follows, dealing with the average results obtained 

 on body weight, effect on the blood and urine, and the metabolism 

 of nitrogen and phosphoric acid : 



THE WEIGHT OF THE BODY. 



If all the variations in weight be taken as a whole for the nine 

 men who completed the periods, it is noticed that there is a gradual 

 diminution in weight, which falls from 62.71 kilograms with an 

 average of 555 grams of dry food per day in the fore period to an 

 average of 62.27 kilograms with an average of 564 grams of dry food 

 per day in the preservative period. This loss of weight is continued 

 in a more marked degree in the after period, where the average 

 weight is 61.61 kilograms with 568 grams of dry food. Thus, altho 

 the quantity of food is increased, the weight of the body is dimin- 

 ished. The general conclusion, therefore, in regard to the effect of 

 the preservative upon the weight of the body is that there is a greater 

 waste than there is a building up of the tissues, assuming, as we may 

 practically do, that the amount of energy and the temperature 

 remain reasonably constant. The general effect, therefore, of the 

 salicylic acid is, under the conditions specified, to diminish the 

 weight of the 'body; in other words, to interfere with the processes 



