180 VETERINARY BACTERIOLOGY 



to the injection of the bacterial proteins or extracts or to the dead 

 bodies of the organism. It has been found, for example, if the dead 

 organisms, or extracts from them, be rubbed into the skin of an 

 infected individual, an inflammation, marked by some edema, 

 redness, and frequently the formation of papules, will occur. 

 This is true in tuberculosis and some other diseases. That this is 

 one of the manifestations of anaphylaxis seems probable. The 

 injection of tuberculin, consisting of dead tubercle bacilli and their 

 products of growth, into an animal having tuberculosis will cause 

 a characteristic rise in temperature, and is, therefore, of great 

 diagnostic value. This reaction resembles the anaphylactic 

 reaction in many ways. For example, a second injection following 

 soon after the first will give no reaction; probably the body is 

 in a state of antianaphylaxis. Furthermore, advanced cases 

 of the disease do not respond perhaps they are either constantly 

 antianaphylactic or show anaphylactic immunity due to the 

 constant presence of large numbers of organisms in the body. 

 On the other hand, there are some unexplained differences between 

 this reaction and that typical of anaphylaxis produced by other 

 proteins. Many points remain still to be explained. That it is, 

 however, of a similar nature seems to be altogether probable. A 

 similar reaction may be secured with the emulsion of dead Bacillus 

 mallei (mallein) in glanders. 



