224 VETERINARY BACTERIOLOGY 



Experimental Evidence of Pathogenesis. The organisms pro- 

 duce a fatal disease in mice, guinea-pigs, and sometimes rabbits, 

 but the white and brown rat, dog, and sheep are found to be 

 immune. Inoculation into the goat revealed the fact that the 

 disease could be produced only with difficulty, yet enough evi- 

 dence was secured to make the demonstration of the organism 

 as the etiologic factor satisfactory. 



Disease Produced. The disease produced in the Angora goat is 

 characterized by symptoms of diarrhea, by pneumonia, great 

 emaciation, and weakness. It is generally fatal. The visible 

 mucous membranes are anemic. The anemia is even more marked 

 on postmortem examination. The lungs show inflammatory 

 changes; the exterior is frequently mottled, showing much the 

 appearance of pneumonia in process of resolution. Degenerative 

 changes are also to be observed in the heart and the kidneys. 



Immunity. There is no evidence of toxin production. At- 

 tempts at immunization by injection of broth nitrates into guinea- 

 pigs revealed the development of some increased resistance. 

 Efforts at practical immunization were unsuccessful. Nothing 

 is known of the agglutinins, opsonins, or bactericidal properties 

 of the immune serum. 



Bacteriologic Diagnosis. Cultures from the blood, or stained 

 mounts from this source, should reveal the characteristic organism. 



Transmission. Methods of transmission are not certainly 



known. 



Micrococcus gonorrhoeas 



Synonyms. Diplococcus gonorrhoea, gonococcus; diplococcus 

 of Neisser. 



Diseases Produced. Gonorrhea and its sequelae in man. 



Neisser, in 1879, noted the occurrence of a characteristic coccus 

 in gonorrheal pus. Bumm, in 1885, succeeded in obtaining the 

 organism in pure cultures, and determined by inoculations into 

 human subjects the causal relationship of the organism to the 

 disease. 



Distribution. Gonorrhea is a common disease in all classes of 

 men, particularly in civilized countries. 



Morphology and Staining. The gonococcus closely resembles 

 the meningococcus. In stained preparations of gonorrheal pus 



