ACTINOMYCES GROUP 381 



of difficulty. Upon agar the growth appears in two to three days 

 as small, brownish colonies. It is somewhat more luxuriant upon 

 glycerin and maltose agar, the colonies coalescing to give the 

 growth a moist, mealy appearance. The colonies are light brown 

 in color. Growth upon potato is similar. In bouillon the colonies 

 develop upon the surface as fine dry disks, and form a pellicle, 

 which finally settles as a sediment, the broth remaining clear. 



Physiology. The organism is a facultative ae'robe. 



Pathogenesis. The organism produces tubercle-like lesions 

 in the rabbit, guinea-pig, and monkey upon inoculation. It is not 

 of any considerable economic importance. 



Actinomyces madurae 



Synonym. Streptothrix madurce. 



Disease Produced. Madura foot, mycetoma, streptothricosis 

 in man. 



Vincent, in 1894, cultivated an Actinomyces from cases of 

 mycetoma or Madura foot in man. This disease occurs in certain 



Fig. 166. Actinomyces madurce, stained mount from culture (Musgrave, Clegg, 

 and Polk, in " Philippine Journal of Science "). 



tropical countries, as southern Asia and the Philippines. It is 

 undoubtedly a different species from those already described. It 

 is not known to affect animals in nature, but will infect the monkey 

 upon intraperitoneal inoculation. 



