THE LUXG TLAGUE. 49 



2. In order to prevent, as much as possible, its unfavorable consequences, it is neces 

 sary to use some precaution, both in the selection of the matter for inoculation and in the 

 period of its application. The season, the atmospheric circumstances, and the state of nutri 

 tion, exert considerable influence upon the success. The autumn appears, for more than 

 one reason, to be the most suitable time. 



3. When an intense action and serious casualties appear locally and in the more dis 

 tant organs, they may be attributed to exterior circumstances and to the individual con 

 stitution. This being the case, casualties cannot always be avoided. 



4. If serious complications appear and affect the essential organs so as to cause the 

 reaction of the whole organism, it is as difficult to prevent them and arrest their progress 

 as it is to cure pleuropneumonia. 



5. In the violent cases, terminating in death, lesions in the thorax or the lungs have 

 never been met ; hitherto they have always been concentrated in the abdominal cavity. 



6. The inoculation produces no unfavorable effects, either upon the constitution or 

 the yield of milk, while its action is limited to a local affection. Only in the cases where 

 abundant deposits succeed a too intense local action do the animals continue sickly during 

 a considerable period of time. 



7. The operation has not had a determined influence on the excitement of oestrum. 

 In proportion this has been more frequent on the inoculated than on the uninoculated cows. 

 It is, however, to be remarked that No. 25 has not yet been in heat, although the period 

 for it has long since passed. 



8. The return of the uterine heats with the two cows Nos. 5 and 12, probably in con 

 sequence of abortion, can the less be referred to the inoculation, as these two cases are 

 isolated and the effects were not observed in Nos. 19, 21, and 23, which were very mark 

 edly subject to sexual excitement. 



9. It cannot be determined with complete certainty whether the premature partu 

 rition of a cow near her time, (No. 10,) as well as the consecutive phenomena observed in 

 the mother and the calf, are to be attributed to the inoculation ; it is the same with the 

 cow No. 14, which calved before her time. These circumstances are, however, of a nature 

 to discourage the inoculation of females in an advanced stage of gestation. 



10. As abortion is frequent in the course of pleuropneumonia, it cannot be passed 

 over in silence that this complication has never appeared with the beasts that have suffered 

 so seriously from the inoculation as to sink under it. If, therefore, the operation has any 

 influence upon gestation, it can be only in the last stage. 



11. The hypothesis already proposed in our&quot; first report, that the evolution of pleuro 

 pneumonia after the inoculation ought to be attributed to the existence of the germ of the 

 disease before the operation, notwithstanding the absence of every morbid phenomenon, 

 acquires a higher degree of probability from our experiments. 



12. The opinion of those who hold that cattle which have had pleuropneumonia and 

 have recovered do not contract it a second time, or at least rarely, and that the inoculation 

 is performed without success upon these individuals, is again confirmed by No. 16, which 

 was inoculated twice, but in vain. 



13. Our experiments furnish the remarkable proof that a power, at least temporary, 

 of insuring against the contagion of pleuropneumonia cannot be denied to the inoculation ; 

 it remains uncertain, however, to what extent the predisposition to contract this disease is 



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