52 DEPAKTMENT OF AGRICULTURE. 



After an elaborate analysis of cases in which the inoculation seems to have been 

 effectual, of others in which the operation and immunity seemed to be coincidences, and, 

 lastly, of those in which it was not preservative, the commission concludes : 



1. That the inoculation with the liquid extracted from a lung hepatizcd in consequence of exudative plenropneu- 

 inonia is not an absolute preservative against that disease. 



2. That the phenomena succeeding the inoculation may occur several times upon the same animal, whether it has 

 or has not been aflected with exudative pleuropm umonia, and that the two aft ections may go on simultaneously in one 

 and the same individual ; considerable derangements appear at the inoculated part, while the morbid action of the lungs 

 progresses toward a fatal termination. 



As to the point whether inoculation really possesses a preservative virtue, and, in -that case, in what proportion 

 and for what duration it maintains the immunity in the animals that have undergone it, this question can bo resolved 

 only by ulterior researches. 



A summary of inoculations performed and results obtained is appended in a tabular 

 form at the close of the report. 



We now come to the experiments of the French commission, and it must not be for 

 gotten that, in connection with the subject of the transmission of the lung plague by con 

 tact, this commission had resorted to inoculation independently of any suggestions on the 

 part of Dr. Willems. 



The general resumd, ably set forth by Professor Bouley, is regarded up to the present 

 day as having done much to diffuse a rational belief in the efficacy of inoculation, and the 

 experiments were conducted with great care and skill. 



Experiments were instituted by the commission 



First. To ascertain whether pleuropneumonia is susceptible of being transmitted to 

 healthy animals by the inoculation of blood, saliva, nasal discharge, and excrementitious 

 matters from animals affected with the disease. 



Second. Have animals thus inoculated enjoyed any immunity against the contagious 

 influence of the lung plague ? 



Third. Is pleuropneumonia capable of being transmitted, in all its forms and char 

 acteristic symptoms, to healthy cattle by the inoculation of the liquid extracted from the 

 lungs of a sick animal ? 



Fourth. In the case where inoculation of this liquid does not determine on healthy 

 animals an exact repetition of the form and symptoms of the original disease, what are 

 the local or general phenomena which result ? In what proportion and to what extent do 

 these characters, more or less severe, transmit themselves ? How many animals die after 

 inoculation? How many recover their health after having been subjected to this test, 

 and under what conditions ? 



Fifth. Do the animals subjected to this proof of inoculation with pulmonary liquid 

 acquire the power of resisting the contagion of pleuropneumonia? 



The experiments made to solve the question whether pleuropneumonia is contagious 

 by the inoculation of the blood, saliva, nasal mucus, &c., having been performed only on 

 six animals, the commission has not deemed them sufficient in number to form the basis of 

 any conclusion. Nevertheless, it was thought right to mention that the two cows inocu 

 lated with the nasal discharge, and subjected to the proof of contagion by cohabitation, 

 have not been affected with pleuropneumonia. 



Experiments by inoculating the liquid from the lungs of sick cattle have been per 

 formed on fifty-four healthy animals, and under conditions which indicated that these ani 

 mals had never previously contracted the disease. Of these fifty-four subjects inoculated 



