THE LU^G TLAGUE. 53 



none have shown symptoms of pleuropneumonia as the result of inoculation. On twenty- 

 three the effects of inoculation have only been indicated by a slight local and well-circum 

 scribed inflammation. On twenty-one the inflammation has been very severe, very exten 

 sive, and complicated by gangrenous phenomena which have led to the death of six subjects. 

 Therefore the number of animals in which inoculation has been benignant has amounted 

 to 61.11 per cent.; the proportion of those having gangrene after the operation, which 

 resulted in the loss of a portion of the tail, was 27.77 per cent. ; lastly, the deaths attained 

 11.11 per cent. Thus 88.88 per cent, of the inoculated animals recovered, and 11.11 per 

 cent. died. 



Of the forty-eight subjects which came out of the inoculation safe and healthy, two 

 died of accidents not induced by the operation, and thirty-four were exposed for a period 

 of five or six months to the direct influence of contagion by cohabitation with twenty-four 

 subjects that had not been inoculated, and which served as a means of comparison. 



Twelve inoculated animals which had been placed in separate stables to serve for 

 ulterior experiments were not exposed to the direct contact of such cattle, but were looked 

 after by the same person who had charge of the sick animals. 



Only one of the forty-six animals inoculated, viz., about two per cent., became affected 

 with pleuropneumonia, whereas of the twenty-four non-inoculated animals fourteen, or 

 fifty-eight per cent., suffered. 



Prom these experiments the commission concludes 



1. The inoculation of the liquid extracted from the lungs of an animal affected with 

 pleuropneumonia does not transmit to healthy animals of the same species the same disease 

 at all events, so far as its seat is concerned. 



2. The appreciable phenomena which follow the inoculation are those of a local inflam 

 mation, which is circumscribed and slight, on a certain number of the animals inoculated; 

 extensive and diffuse, with general reaction proportioned to the local disease, and compli 

 cated by gangrenous accidents, on another number of the inoculated animals, so that even 

 death may result. 



3. The inoculation of the liquid from the lungs of an animal affected with pleuropneu 

 monia exerts a preservative influence, and invests the economy of the larger number of 

 animals subjected to its influence with an immunity which protects them from the conta 

 gion of this malady during a period which has yet to be determined, but which the experi 

 ments quoted indicate, at all events, not to be less than six months. 



Although, from the experiments of the commission, the losses per cent, among the 

 animals inoculated were greater than the losses by the disease communicated by cohabita 

 tion, they ascribed this partly to the imperfect means adopted in inoculating, and they do 

 not overlook the great deterioration of the animals which did not die after suffering from 

 the natural disorder. They recommended further trials, and that the practice should be 

 encouraged. 



A mixed commission of the Central Society of Medicine and the Agricultural Committee 

 of Lille instituted experiments on one thousand two hundred and forty-five animals, to de 

 termine the comparative effects of inoculation of the pulmonary liquid of pleuropneumonia 

 and of septic matters. The inoculations with virus amounted to one thousand two hundred 

 and sixteen ; of these nine hundred and seventy-eight succeeded, and two hundred and 

 thirty-eight showed no visible effects. One hundred and seventy-nine animals, or 14.72 



