336 HIPPURIC ACID. 



clilorine at a slightly elevated temperature, it is con 

 verted into Moracetyl benzene C 6 IP.CO.CH 2 C1 (crystal 

 line; fusing point, 41 ; boiling point, 246). Yields 

 nitrosubstitution-products with nitric acid. Hydrogen, 

 in statu nascendi, converts it into secondary phenyl- 

 ethyl alcohol (p. 316). Oxidizing agents convert it 

 into benzoic and carbonic acids. 



Ethylphenylketone, C 6 H 5 .CO.C 2 H 5 . Is prepared 

 by the action of benzoyl chloride on zincethyl. Boil 

 ing point, 208-212. Insoluble in water. Yields by 

 oxidation benzoic and acetic acids. 



mric acid (Benzoylglycocol) C 9 H 9 ]TO 2 = 

 CH 2 &amp;lt; pQ QTT Occurs in small quantity in normal 



human urine, in large quantity in the normal urine of 

 graminivorous animals. Toluene, benzoic acid, cinna- 

 mic acid, and oil of bitter almonds, taken into the 

 system, are converted into hippuric acid in all animals ; 

 quinic acid, in the case of man and graminivorous 

 animals, likewise undergoes the same change. Ob 

 tained artificially, by the action of benzoyl chloride 

 on glycocol-zinc or glycocol-silver (p. 85). To prepare 

 it, fresh urine of horses or cows is evaporated to about 

 one-fourth its volume, and then acidified with hydro 

 chloric acid, the hippuric acid being thus thrown 

 down as a crystalline magma. The yield varies very 

 much, according to the fodder of the animals, and ac 

 cording as they have lived in stalls or in the open air. 

 The crude acid is washed out with cold water, pressed, 

 digested with a large quantity of chlorine water, and 

 finally dissolved in it at boiling temperature. On 

 cooling it separates in colorless needles. Or the crude 

 acid is dissolved in boiling weak soda-ley, sodium 

 hypochlorite gradually added until the color is removed, 

 and then, when the solution has ceased boiling, hydro 

 chloric acid is added until the whole has an acid 

 reaction. It is completely purified by recrystallizing 

 from water. 



