100 CIRRHOSIS OF LIVER, 



chyma, from diseases of the vascular connecting 

 tissues. Andral in the main supported this theory 

 except that he bestowed greater prominence upon the 

 distinctions between the red vascular portion and the 

 yellow secreting tissues of the gland ; and looked upon 

 those abnormal granulations as hypertrophy of the 

 latter, accompanied by atrophy of the red vascular 

 portion, which in many cases appeared to be converted 

 into fibrous tissues. Cruveilheir steps forward and 

 disputes the existence of two different substances in 

 the liver, and considers the disease under discussion 

 to be the result of atrophy of one portion of the gland, 

 with hypertrophy of the other portion. Becquerel 

 constructed a new theory altogether, and maintained, 

 that the so-called yellow substance was the peculiar 

 seat of the disease, and further thought that it became 

 infiltrated with an albuminous substance which was 

 followed by hypertrophy ; that the red vascular portion 

 was compressed by it, and became atrophied, and that 

 at a more advanced stage the yellow substance itself 

 became likewise atrophied. 



That eminent pathological anatomist, Carl Rokitansky, 

 distinguishes two different modes of origin of Cirrhosis 

 of the liver, the one proceeding from a morbid develop- 

 ment of the capillary blood-vessels, owing to an 

 excessive secretion of bile ; the other due to a chronic 

 inflammation of the hepatic parenchyma. 



Oppolzer attributes the disease mainly to partial 

 impermeability of the finest ramifications of the portal 

 vein, resulting from inflammation and obliteration, or 

 from lateral compression by the bile ducts, which are 

 enlarged, or, loaded with fat. 



