106 PATHOLOGY OF SECOND STAGE OF CIRRHOSIS. 



portions constitute the substance of the granulations, 

 and may remain for a certain period intact ; but in the 

 further and more advanced progress of the disease these 

 cells likewise undergo great changes, which materially 

 interferes with their healthy and normal functions, from 

 the deposit of fatty substances, and various kinds of 

 pigments, the result of a deranged nutrition of the liver, 

 produced by a slow and latent inflammation. The 

 deposit of pigment, from which the term cirrhosis 

 (yellow) is derived, is but seldom absent. This is 

 caused by the hypertrophied connective tissue pressing 

 against the extreme radicles of the bile-ducts, and thus 

 Diving rise to a retention of the secretion, followed by 

 an icteroidal condition of the liver. This colouring 

 matter accumulates in the form of a fine orange, or 

 sulphur yellmv-granr,: ides this there is another 



colour to be met with in a cirrhotic liver, which is of a 

 dirty red-brown or black pigment, the result of decom- 

 position of the red globules of the blood. There i- 

 increase in the amount of connective (areolar) tissue. 

 This increase is lii-t met with in the prolongations of 

 "(Hisson's capsule," which accompany the finer sub- 

 divisions of the vessels in the remotest parts of the 

 interior of the liver; from this it gradually proceeds 

 to invade the substance of the "lobules," and by 

 degrees increases so in breadth as finally to destroy the 

 whole secreting portion of the organ. The vascular 

 apparatus also does not escape the ravages of chronic 

 atrophy of the liver. The trunk and large branches of 

 the portal vein have been found considerably enlarged, 

 and filled with clots of blood ; the smaller branches nar- 

 rowed or totally destroyed to an extent proportionate to 



