96 REPORT OF THE BUREAU OF ANIMAL INDUSTRY. 



No. 372 had been exposed in a pen, infected with hog cholera, to the lung dis- 

 ease. It had therefore been exposed to two different diseases. It began to grow 

 weak and stupid, eating very little until death, on March 20, more than a month 

 after the earliest symptoms of disease. This animal was found with extensive lung 

 disease, while its internal organs contained hog cholera bacteria, as the following 

 remarks indicate. 



Animal with moderate amount of fat. Stomach bile-stained. Gall bladder filled 

 with a thick prune-juice colored mass. Beginning sclerosis of liver. No intes- 

 tinal lesions. Lungs. Right ventral and left ventral lobes almost entirely solidified. 

 Median ventral and cephalic border of right principal lobe solid, exceedingly hard 

 to the touqh ; pleura covering it thickened. On section the lung tissue is found con- 

 verted into a grayish, homogeneous, caseous mass. In left principal lobe a mass 

 of tissue about 2 square inches in extent is solidified, some lobules being caseous, 

 others still red. In the hepatized ventral lobes there are many lobules converted 

 into a yellowish- white, homogeneous mass, almost cartilaginous. The small 

 bronchi exude a glairy purulent mucus. 



In the recent lesions bacteria few in number; in the caseous masses immense 

 numbers, nature not determinable. 



Liquid cultures from blood and spleen contain not swine plague but hog cholera 

 bacteria. A gelatine culture from the blood contains the same bacteria. A rabbit 

 inoculated subcutaneously with one-fourth cubic centimeter of a beef infusion 

 culture died on the sixth day with greatly enlarged spleen and coagulation-necro- 

 sis of liver. In both organs the injected bacteria were present in large numbers. 

 Of two mice inoculated with lung tissue one died next day; no examination 

 made. Unfortunately no rabbit was inoculated from the lung tissue. 



Pig No. 372, died March 20. 

 blood lunpc 



2 mice March 22 



one died March 23 



gel. cult. b. i. cult. other not affected 



hog cholera bacteria J 



plate cult. 

 gel. cult. 

 b. i. cult, April 1. 



rabbit, April 2 

 died April 8 

 (hog cholera) 



Pig No. 397 illustrates well the existence of two diseases in the same animal, the 

 hog cholera bacteria being obtained from the spleen, the swine plague germs from 

 the lungs. This animal was fed with the hepatized lung of pig No. 378 on March 

 24, and three days later with lung tissue from pig No. 359, In a week it became 

 feeble, especially in the hind limbs, dull, without desire for food. April 13 diarrhea 

 set in and it died next day. Post-mortem examination revealed extensive disease 

 of the lungs and large intestine. The animal had contracted swine plague first; 

 upon this disease hog cholera was grafted, which probably "was the immediate cause 

 of death. 



Slight discoloration of skin on ventral aspect of body. Superficial inguinal glands 

 enlarged, cortex infiltrated with blood, medulla dotted with petecchias. Some fibrils 

 of coagulated lymph across coils of intestines; small quantity of serum present in 

 abdomen. Mesenteric glands very large, deep red. On section almost entirely in- 

 filtrated with blood, excepting a few patches of the medulla, which are homo- 

 geneous yellowish white; glands of meso-colon dark red. Spleen greatly engorged 

 with blood, friable. In liver the connective tissue increased in quantity; paren- 

 chyma softened. 



In thorax the right pulmonary pleura covered with a thin film of exudate. Con- 

 siderable yellowish serum in both pleural sacs. The cephalic and ventral lobes and 

 the ventral portion of principal lobe hepatized. The hepatization presents that 

 peculiar grayish-mottled appearance on a deep-reel ground; trachea filled with 

 whitish foam. Digestive tract. Stomach filled with a turbid yellowish liquid, 

 nmcosa in general bile-stained, in fundus deeply reddened. In the large intestine 

 the mucosa is uniformly and very densely sprinkled with dark-red points. A dirty, 



