100 



REPORT OF THE BUREAU OF ANIMAL INDUSTRY. 



died next day. . A gelatine and a liquid culture were both pure, containing only 

 swine plague bacteria. At the same time the presence of these bacteria in the peri- 

 cardial cavity of the pig was demonstrated by roll cultures. The presence of swine 

 plague bacteria in both lungs and pericardium was thus amply proved. The latter 

 was also invaded by other bacteria, a vibrio and a streptococcus being among the 

 number. 



Although microscopical examination failed to reveal any bacteria in the spleen 

 of this animal the characteristic motile hog cholera bacteria were obtained from 

 it in both gelatine and liquid cultures. The colonies in the gelatine tube were 

 very few in number. Two mice inoculated therefrom died rather prematurely 

 in twenty-four and forty-eight hours, respectively, with the specific bacteria in 

 the spleen. 



lung tissue 



Pig No. 366. 



I 



rabbit (ear) June 30 



died July 2. 

 (swine plague) 



3 mice 



died July 2, 3 

 (swine plague) 



pericardial exudate 



spleen 



mouse, June 30 



died July 2 

 (swine plague) b. i. cult. gel. cult. 

 (hog cholera) 



(prematurely) 



Within several days of the death of this animal two pigs which had been 

 placed in the same pen died of acute hog cholera, without any hepatization of the 

 lungs. 



Pig No. 414 was placed in the infected pen June 21, for the purpose of keeping up 

 the disease of hog cholera, which was apparently dying out. The animal died July 

 6, after appearing dull for a few days. At the autopsy the lymphatic glands were 

 found but slightly affected, spleen enlarged and very much congested. Lungs 

 normal, excepting a few subpleural petecchiae. Caecum and colon covered with a 

 large number of ulcers, the mucosa of the latter intensely congested. The same 

 was true of the greater curvature of stomach. Very few hog cholera bacteria in 

 spleen. A pure culture was obtained therefrom. 



Pig No. 416, put into the infected pen with No. 414, showed signs of disease July 

 4, and died on the same day. . Skin of abdomen deeply reddened. Lymphatic 

 glands with cortex hemorrhagic. Spleen very large and gorged with Wood. 

 Lungs and heart normal, with exception of a few subpleural ecchymoses. Numer- 

 ous petecchiae on surface and in parenchyma of kidneys. Light hemorrhage into 

 pelvis. Numerous subperitoneal ecchymoses on the large and the small intestines. 

 Besides a general congestion of the mucosa of the latter there are a few small re- 

 cent ulcers in caecum and colon. Hog cholera bacteria quite numerous in cover- 

 glass preparation from spleen. A pure culture obtained therefrom. 



These three cases show that in the same pen two animals may be in contact with 

 a third which has very extensive lung disease and not take the disease. It is barely 

 probable that the period of exposure to the living animal, about eight days, was 

 too brief a time for the transmission of the disease, or else the time elapsing between 

 the exposure to this disease and the death of the animals from acute hog cholera 

 was too short to allow the lung disease to make its appearance. We know as yet 

 too little of this disease to offer anything but opinions concerning its origin and 

 communicability. 



The source of the lung disease in the first animal (No. 366) is likewise very 

 puzzling, when we consider that a number of animals had died of hog cholera 

 without any sign of lung disease. 



BRIEF SUMMARY OF THE FACTS OBTAINED FROM THIS EPIZOOTIC. 



In the fifteen animals which died there was extensive disease of 

 the lungs, excepting an -the- first (Not 1 406)^ which rm&s very likely a 

 case of hog cholera. In most of these the pleura was also involved. 

 In the earliest four cases, excluding the first (Nos. 403, 402, 405, 407), 



