EEPOKT OF THE BUREAU OF ANIMAL INDUSTRY. 127 



horse-chestnut. The contents are whitish, of a putty-like consistency. Attached 

 to the spleen by means of tough, fibrous tissue, evidently part of the omentum, is a 

 Cylindrical encysted mass of the same consistency, 3 to 4 inches long and one-half 

 inch wide. These masses represent without doubt the place where the incompletely 

 sterilized culture liquid was deposited by the needle. 



In the thorax the ventral lobes of both lungs are enlarged, airless, of a pale red- 

 ish, translucent, gelatinous aspect. The bronchi of these lobes are filled with a glairy 

 muco-pus and contain some lung worms. Two rabbits inoculated from an emul- 

 sion of lung tissue both died of hog cholera on the eighth and ninth day. 



No. 482, found dead September 16, had several old ulcers in the large intestine. 

 The lungs were extensively adherent to the chest wall by old fibrous bands, and in 

 part airless and of a pale red color. 



When the Baltimore pig was brought to the station there was what 

 may be considered chronic hog cholera, but no evidence of swine plague 

 as shown by the inoculation of lung tissue from No. 484 into rabbits 

 some time ago, and also the autopsies of the pigs which had died mean- 

 while. The ulcers were probably directly due to the intra-abdom- 

 inal injection of the culture liquid supposed to be sterile, and death 

 was brought on chiefly through peritonitis as the result of the ulcer- 

 ation. If the disease, so chronic in character as to elude detection 

 and to last from three to six months, was still capable of infecting 

 other animals it did not do so, as not only four of the vaccinated 

 pigs but also the four control animals were still alive and apparently 

 well. 



Soon after the arrival of the sick Baltimore pig it was penned with 

 these survivors, and fresh pigs were put in the infected pen as the 

 inmates died. Thereupon pigs died quite rapidly, with lesions indi- 

 cating the presence of 'swine plague and a decided renewal of hog- 

 cholera of a virulent type. Vaccinated pigs died very soon after in 

 quick succession, some with marked swine plague lesions. A pe- 

 rusal of the autopsy notes given below will show that they all suf- 

 fered from old ulceration, except No. 12, which died from injuries 

 received It also appears from the lesions that some of the pigs 

 were very likely infected a second time. As the state of things was 

 very complicated nothing positive can be said as to this point. The 

 notes are simply given to aid in elucidating the subject of swine 

 plague. As to two of the control animals which also died (Nos. 13 

 and 15), it would be very difficult to state from the autopsy notes 

 whether they had been infected from the inoculated animals before 

 September 20 or had contracted the disease from the Baltimore case. 

 Nos. 5 and 6, the other control animals, died of hog cholera contracted 

 evidently after the arrival of the Baltimore pigs, as the notes will 

 show. 



The introduction of the Baltimore pig was followed September 31, 

 eleven days later, by the death of four pigs, Nos. 5, 8, 9, and 11. 



September 31. No. 5, control animal,* found dead this morning. Skin of ven- 

 tral surface of body reddened ; spleen enormously enlarged and congested. Hem- 

 orrhagic foci in lungs, but no hepatization. Large intestine deeply reddened and 

 slightly ulcerated. Numerous hog cholera bacilli in spleen. 



Pig No. 8, vaccinated animal, found dead this morning. Skin and spleen normal. 

 Inguinal glands enlarged, oedematous, reddened. Liver cirrhosed. Kidneys with 

 medulla congested. Stomach empty, mucosa bile-stained. In ileum several ulcers 

 near valve. Mucosa of caecum and upper third of colon almost entirely ulcerated ; 

 farther down ulcers isolated one-quarter to 1 inch across. Rectum intact. Lungs 

 about twice the usual size of collapsed lungs; over both a pleuritic deposit appearing, 

 either as a mesh-work or as minute dots, which give the pleura a roughened aspect, 

 or as a continuous membrane, according to the quantity of exudate. Slight agglu- 

 tination of lobes to chest walls and to one another. In each pleural sac about a tea- 

 epoonful of loose, soft exudate. 



* These terms refer to the vaccination experiment. 



