128 EEPOET OF THE BUEEATT OF ANIMAL INDUSTEY. 



The parenchyma of the hepatized regions is in general red, granular on section, 

 with much reddish serum flowing from the cut surface, but the ventral and cepha- 

 lic lobes are in more advanced stages, some parts being grayish red on section, 

 others containing small foci of a peculiar pale, grayish-yellow color, with outline 

 sharp and sinuous. These are, no doubt, necrotic masses, or sequestra. They are 

 found in the cephalic lobe of the right lung. The same lobe of the left side is in a 

 state of advanced broncho-pneumonia, the smaller air tubes being filled with a glairy 

 muco-pus. The right principal lobe contains also centers of beginning necrosis. 

 In the bronchial and trachea! glands, which are much enlarged, the cut surface 

 shows grayish scalloped lines in a deeply congested ground. Trachea contains red- 

 dish foam. The bronchi contain cylindrical clots of dark and pale color embedded 

 in mucus ; in the smaller bronchi a frothy, thin, red liquid. The immediate cause 

 of death, pulmonary hemorrhage. 



Cover-glass preparations from lung tissue show large numbers of polar-stained 

 swine plague bacteria. A rabbit inoculated therefrom died in eight days. The sub- 

 cutis on the inoculated thigh and contiguous abdominal wall was thickened, pasty, 

 and skirting this a blood-stained, gelatinous exudate. Peritonitis shown by the ex- 

 tensive ecchymosis of the caecum and a grayish, gelatinous exudate covering spleen, 

 liver, and a small portion of the intestine with a layer of variable thickness. This 

 exudate is made up in part of pus corpuscles and great numbers of polar-stained 

 bacteria. These are also abundant in the subcutaneous infiltrate, but rare in heart's 

 blood. An agar culture from the peritoneal exudate contained on the following 

 day a very thin, veil-like growth of swine plague bacteria. 



In the barely enlarged spleen of the pig, hog cholera bacilli can be detected on 

 cover-glass preparations. A roll culture and an agar culture contain the same 

 bacilli only. 



Pig No. 9, eight months old, vaccinated animal. Before this animal was placed 

 in the infected pen it was fed portions of the spleen and large intestine of one of 

 the Baltimore cases on September 20. 



Skin normal ; spleen barely enlarged. Cirrhosis of liver advanced. Kidneys 

 with medullary portion deeply reddened. Lymphatics of meso-colon and near kid- 

 neys enlarged and congested. Stomach contains only a small quantity of bile- 

 stained liquid. Duodenum extensively pigmented. Mucosa of cascurn and upper 

 colon almost entirely destroyed, blackish. Below the middle of the colon the ulcers 

 are isolated. The walls thickened and serosa inflamed where ulcers occur. 



Lungs diseased ; considerable serum in the right pleural sac. The whole of the 

 right lung and the cephalic half of the left hepatized and covered with a pleuritic 

 exudate similar to that in the preceding case. The principal lobe of the right lung 

 is in a state of red hepatization, while the ventral lobe is farther advanced and 

 contains the necrotic foci described under No. 8. The cephalic, ventral, and a por- 

 tion of the principal lobe of the left lung in the same condition as the corresponding 

 lobes of right side. Bronchial glands enlarged, with reddened cortex. Bronchi 

 filled each with a dark, cylindrical clot. From the red hepatized regions cover-glass 

 preparations show polar-stained bacteria in groups. The polar stain could only be 

 made out clearly when the germs were magnified 1,000 diameters. Roll cultures 

 from the lung tissue were useless, owing to the large number of liquefying germs 

 present. A rabbit inoculated by injecting cubic centimeter of sterile water in 

 which a bit of lung tissue had been torn up died in three days with a pasty infiltra- 

 tion of the subcutis of thigh and abdomen, slightly blood-stained; in one groin the 

 subcutis very emphysematous. Liver and kidneys congested; spleen scarcely en- 

 larged. Peritoneum of caecum roughened; extravasations in meso-rectum. Im- 

 mense numbers of polar-stained bacteria in subcutis as well as on inflamed perito- 

 neum. Very few in spleen and blood. Two agar tubes from blood and spleen 

 contained an abundant growth of the same germs next day. A gelatine roll culture 

 from the blood remained sterile. 



From the pig's spleen an agar culture contained only hog cholera bacilli. In a 

 roll culture from a bit of spleen tissue about 200 colonies of the same germ and one 

 producing liquefaction. 



Pig No. 11, vaccinated, about eight months old ; found dead this morning. Skin 

 normal; spleen not enlarged. Lymphatics of large intestine (meso-colon) enlarged 

 and deeply reddened; glands in other regions of the body enlarged, pale. Liver 

 cirrhosed. Kidneys not changed. Stomach empty ; mucosa bile-stained, along 

 fundus highly congested. Large patches of superficial ulceration in lower jejunum 

 and ileum. In caecum and upper colon the mucosa is almost completely destroyed, 

 and the surface appears as if charcoal dust had been rubbed into it. Walls much 

 thickened. Very curiously a large diverticulum near the valve, forming a pouch, 

 has its mucosa intact. Ulceration gradually disappears near rectum. 



The lungs are also implicated, but there is no pleuritis. In all lobes are masses of 



