REPORT ON DOURINB. 



put to a mare suffering from Dourine in order to test whether a 

 relapse would take place or a fresh infection be brought about. 

 On the eighth day following the primary covering paraphymoeia 

 app-'aivil and on the eighteenth a cutaneous plaque, in blood drawn 

 from which the trypanosoma was found. During* the next twelve 

 weeks seventeen further places made their appearance, together 

 with eruptions of disseminated urticaria at intervals. CEdema of 

 the throat extending to the chest, followed by weakness and later 

 loss of power over the hind quarters, haemoglobin uria and death. 



Experimental cases of Dourine in Equities and small animals. 



Mare 1.* Covered by Arab stallion Shamsher, the subject 

 of chronic Dourine. Disease not communicated. Six weeks later 

 served by a second horse Kilngarth (thorough-bred English), 

 the subject of more recent disease. After further period of three 

 weeks, congestion of vaginal m. m. observed and first cutaneous 

 plaque appeared SO days after union with second horse. Appear 

 ance of 27 plaques and several distinct eruptions of disseminated 

 urticaria during a period of 20 weeks. Swelling and oedema of 

 vaginal m. m. which later extended to perineum and udder. Swell- 

 ing and hardening of submaxillary glands. Sexual excitement 

 more or less present during^ whole period the disease lasted. 

 Weakness followed later by complete loss of power over hind 

 quarters. Trypanosomata frequently found in the blood of the 

 plaques, but never free in that of the general circulation. Vaginal 

 secretion, although frcquently^examined, never revealed the presence 

 of the protozoon. Course of disease from date of covering by 

 Kilngarth until that of death, 175 days. Mare covered on several 

 occasions during June 1903 by apparently healthy horso Vendor, 

 but no external genital manifestation's of the disease followed in 

 the mare as a result of the union. 



Mare II. Covered by Arab stallion Yadgir, subject of the 

 latent form of Dourine, symptoms of which had suddenly become 

 active. Appearance on 10th day following covering of vesicles 

 and ulcers on left labium pudendi and later by oedema of vaginal 



' Marea NOB. I to IV inclusive woro Australians. 



