8 REPORT ON DOORINtf. 



m. m. and other minor symptoms. Trypanosoma discovered in 

 vaginal mucus on 34th day, persistence of protozoon at intervals 

 during many months. Eruption of but four cutaneous plaques 

 between the 116th and 284th days, with two intermissions lasting 

 34 and 134 days respectively. Absence of cerebro-spinal- symp- 

 toms during 295 days after covering. 



Mare III. Scarification of minute portion of mucous- mem- 

 brane of left labium vaginae with a needle, and inoculation of trace 

 of fresh blood obtained from a Dourine plaque on English thorough- 

 bred stallion Kilngarth. Appearance on 12th day of vesicle 

 followed by a small ulcer, which readily healed. Swelling and 

 cedema of L. labium, which later involved whole external genitals 

 and perineum, Vaginal mucus contained the trypanosoma of 

 Dourine. A leucodermic area appeared on the vulva on the 57th 

 day after the separation of film-like scab. First plaque appeared 

 on the 34th day following inoculation, in the blood of which 

 trypanosomata were found on microscopical examination, followed 

 at intervals, during a period of 117 days, by successive crops of 

 plaques, numbering 80 in all, which involved the skin of the body 

 and negk. Slight enlargement of the submaxillary glands. Weak- 

 ness, later dragging of the hind limbs whilst walking. Swelling 

 and suppuration of near hind limb. Inability to stand. Destruc- 

 tion. Post-mortem. Course of the disease 60 days. 



Mare IV. Scarification of m. m. of R. labium pudendi, and 

 inoculation of trace of fresh blood obtained from a Dourine plaque 

 on English thorough-bred stallion Kilngarth. Tumefaction of 

 both labia on 15th day, and cedema of perineum. Absence of the 

 trypanosoma from vaginal mucus. First plaque appeared on 70th 

 day following inoculation (presence of trypanosomata demonstrated) 

 followed at intervals during a period of 105 days by successive 

 crops of plaques, numbering 18 in all, which involved the skin of 

 the body and neck. Slight enlargement of maxillary glands. 

 Gelatinous infiltration of subcutaneous and deep structures in various 

 parts of the body. Stiffness, later dragging of the hind limbs whilst 

 walking. Amelioration of symptoms, considerable improvement 

 in condition. Further eruption of a plaque after intermission, last- 

 ing 97 days. 



