REPORT ON DOURINB, 1 '> 



coming with regard to the symptoms exhibited by the great 

 majority of animals when in the district. 



The experimental cases in mares, however, have brought forward 

 some interesting facts, and these show that, if we have any cause to 

 suspect the presence of Dourine in any given equities, we ought to 

 be on the alert any time between 10th and 50th day after the 

 date of the primary covering. According to one observer, symptoms 

 may appear on the eighth day, BO that in a country where the disease 

 is enzootic, it would be more than advisable to keep a careful watch 

 from the date of covering. In some of the experimental cases here 

 brought forward the primary symptoms have been more or less 

 marked by being complicated with Coital Exanthema ; but as this 

 secondary infection may complicate any covering, it is of interest to 

 note how fur Vesicular Exanthema may be the means of cloaking 

 the symptoms of Hourine in the early stages of the latter disease. 



If we analyse the symptoms of uncomplicated Dourine in mares 

 which may appear in the early stage between covering or inoculation 

 and the eruption of the first cutaneous plaque, we find several 

 which convey information and help towards coming to a diagnosis. 



These are (i) Congestion of the vaginal in. m. together with the 

 formation of a vesicle, or vesicles, which later form ulcers on the 

 affected part or on the mucous-membrane of the internal surface 

 of the labia-pudendi. 



(ii) Unilateral or bilateral tumefaction of the labia more or less 

 persistent. 



(iii) Swelling and oedema of the vaginal mucous-membrane 

 producing a patent condition of the vulva during the period for 

 which it persists. 



When all these three symptoms are present, it would lead one 

 to suspect that we might have to do with a case of Dourine, and a 

 careful watch should be maintained for further symptoms. It fre- 

 quently happens, however, that only one or two of these symptoms arc 

 developed, as for instance in the cases of the following animals: 



Alare I exhibited symptom No. (ii) only. 

 II No. (i) only. 



III Nos. (i) and (ii). 



i, IV NOB. (i), (ii), and (iii). 



