REPORT ON DOUR1NE. 



body, waiting to become active whenever the state of the system 

 may become favourable for its further development. In some ani- 

 mals the disease has been known to remain latent for more than 12 

 months and in the cases of Vendor, thorough-bred Australian, 

 and Yadgir, an Arab, it would appear probable that periods 

 verging upon 10 months had been passed through without further 

 symptoms being developed. On the other hand, on reference to 

 Table No. II it may be observed that in Monarch's case only 34 

 days elapsed between the date of covering mare III and the 

 appearance of well-marked cutaneous lesions. The following ex- 

 perimental cases in equines may be divided into two series : 



(a) Those in which the disease was communicated from diseased 

 to the healthy animal, male or female, during covering. 



(6) Subcutaneous inoculation of blood drawn from a plaque or 

 the general circulation of an affected animal : 

 The results were as follows : 



fa] Of five jnares covered respectively by an English and 

 Arab stallion the interval between the date of cover- 

 ing and the appearance of the first plaque occupied 

 30, 32, 24, and 33 days respectively, while in the 5th 

 mare the interval which elapsed was 116 days. 

 () Two mares were inoculated with blood taken from a 

 plaque (Kilngarth No. 12) within a period of 15 to 

 20 minutes of each other. Mare III received the 

 primary blood collected after a small incision had 

 been made in the plaque, whereas mare IV was in- 

 oculated with the second blood drawn later from the 

 same incision. The former animal exhibited cutane- 

 ous plaques after a period of 34 days, while the latter 

 occupied a period of 70 days before similar symptoms 

 became apparent. 



An Arab stallion Monarch and a country-bred donkey stal- 

 lion were utilized for experiments ; the former contracted the disease 

 by covering, while the latter was subcutaneously inoculated with 

 blood from the general circulation. The periods occupied between 

 covering and inoculation respectively and the appearance of the 

 primary cutaneous plaque occupied 34 and 33 days. 



