REPORT ON DOURTNE. 



One half of a plaque may disappear and the other half persist 

 or extend, increasing in dimension in the opposite direction. 



A circular plaque 3'25 inches in diameter may persist for several 

 (3) days and then assume a kidney-shaped form 1*5 by 0'5 inches 

 previous to disappearing. 



Exercise, as for instance walking uphill from the stable to the 

 Laboratory, a distance of three hundred yards, sometimes was 

 sufficient to make a recently-formed plaque fade and disappear 

 within a period of one hour. 



When a well-raised plaque which has persisted for a period 

 begins to lose the meniscus form and become flat, or when a plaque 

 commences to spread, it generally fades and disappears within a 

 few days at most. 



When a number of plaques appear at or about the same time 

 (Yadgir Nos. 25 27), they not uncommonly fade and disappear 

 on or about the same date. 



The plaques which persist for the longest period are nearly 

 always situated upon the neck or crest. The ratio of persistence of 

 plaques on the neck to those on other parts of the body being as 

 2*5 to 1 respectively (Kilngarth). 



Equines, the subjects of Dourine, which exhibit no plaques 

 during the course of the disease, lose most in condition and more 

 quickly than those which exhibit such symptoms. 



(VI) The length of the individual paroxysms and intermis- 

 sions. Of the 14 experimental equines which contracted Dourine, 

 two presented exact similarity with regard to the symptoms ex- 

 hibited. The number of paroxysms varied from a total of 3 to 31 

 in the course of the disease. In all cases the shortest period occu- 

 pied by a paroxysm was 24 hours and under, while the longest 

 period observed was 4> days. The number oE plaques which 

 appeared during the persistence of paroxysms varied from a mini- 

 mum of 1 to a maximum of 16. The number of intermissions in 

 the animals which succumbed tallied with that of the paroxysms, 

 while in those which survived they are one less than that total. 

 The shortest period during which an intermission lasted was 1 day 

 and the longest 138 days. 



