REPORT ON DOURINE. 



TABLE III 



Showing the length oj the individual paroxysms and intermistions 

 in fin- A. class of animals, respectively. 



(VII) Persistence of cutaneous plaques. Plaques in the great 

 majority of cases appear but once, and after persisting for a longer 

 or shorter time begin to fade and disappear slowly or suddenly, but 

 in a number of animals a percentage of the plaques after an inter- 

 val of a few days reappear on the same spot and frequently present 

 a similar outline to that exhibited on the first occasion. After a 

 varying number of days the plaque disappears for the second time, 

 but may again, after a second short interval, make itself manifest 

 for the third time. Details concerning points of interest in this 

 connection with the several appearances of the plaques may be 

 observed in the accompanying table. It must be understood that 

 there is a difference between the course of the reappearance and the 

 third appearance of a plaque within a few days of the disappear- 

 ance of the first and second, and that of a totally new plaque which 

 may appenr later in the course of the cutaneous symptoms and 

 occupy either a smaller or larger area than that previously taken up. 

 This matter is mentioned for the reason that the pathological 

 changes which take place in the two forms of plaques are different. 

 The cause of a primary plaque is similar to that which may appear 



